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FLASH GENE
Symbol TMPRSS11A contributors: mct/npt - updated : 02-02-2008
HGNC name transmembrane protease, serine 11A
HGNC id 27954
Location 4q13.2      Physical location : 68.776.018 - 68.829.232
Synonym name
  • epidermal type II transmembrane serine protease
  • esophageal cancer-susceptibility gene 1 protein
  • airway trypsin-like protease 1
  • Synonym symbol(s) ECRG1, MGC133183
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 53.21 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2428 - 421 - Hobson (2004)
    10 - 2419 - 418 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
     mouthtongue   
    Respiratoryrespiratory tracttrachea   
     respiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be a candidate tumor suppressor gene for esophageal cancer (EC) involved in cell-cycle control (Yueing 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in esophagus cancer (Yueing 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS