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FLASH GENE
Symbol TMOD3 contributors: mct - updated : 12-10-2016
HGNC name tropomodulin 3 (ubiquitous)
HGNC id 11873
Location 15q21.2      Physical location : 52.121.824 - 52.204.329
Genatlas name tropomodulin 3
Synonym symbol(s) UTMOD
DNA
TYPE functioning gene
STRUCTURE 82.51 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status tentative : very preliminary evidence
Physical map
LOC390584 15 similar to putative intramembrane cleaving protease; presenilin-like protein 2; intramembrane protease 3 FGF7 15q15-q21.1 fibroblast growth factor 7 (keratinocyte growth factor) MDS009 15q15.3 x 009 protein LOC388120 15 hypothetical gene supported by BC013357; NM_016120 ATP8B4 15q15.3 ATPase, Class I, type 8B, member 4 SLC27A2 15q21.2 solute carrier family 27 (fatty acid transporter), member 2 HDC 15q15-q21 histidine decarboxylase GABPB2 15q15.2 GA binding protein transcription factor, beta subunit 2, 47kDa FLJ10038 15q15.3 hypothetical protein FLJ10038 USP8 6p21.3 ubiquitin specific protease 8 TRPM7 15q21 transient receptor potential cation channel, subfamily M, member 7 SPPL2A 15q15.3 putative intramembrane cleaving protease AP4E1 15q15.2 adaptor-related protein complex 4, epsilon 1 subunit LOC388121 15 similar to TNF-induced protein CYP19A1 15q21.1 cytochrome P450, family 19, subfamily A, polypeptide 1 FLJ11181 15q15.3 hypothetical protein FLJ11181 CRG-L2 15q15.3 likely ortholog of mouse cancer related gene - liver 2 RC3 15q15.3 rabconnectin-3 SCG3 15q21 secretogranin III MGC35274 15q21.1 hypothetical protein MGC35274 TMOD2 15q21.1-q21.2 tropomodulin 2 (neuronal) TMOD3 15q21.1-q21.2 tropomodulin 3 (ubiquitous) LOC123169 15q21.1 senescence downregulated leo1-like MAPK6 15q21 mitogen-activated protein kinase 6 BCL2L10 15q21 BCL2-like 10 (apoptosis facilitator) GNB5 15q21 guanine nucleotide binding protein (G protein), beta 5 MYO5C 15q21 myosin VC MYO5A 15q21.1 myosin VA (heavy polypeptide 12, myoxin) EEF1B1 15q15.1-q15.3 eukaryotic translation elongation factor 1 beta 1 ARPP-19 15q15.3 eukaryotic translation elongation factor 1 beta 1 FLJ10980 15q21.1 hypothetical protein FLJ10980 ONECUT1 15q21.1-q21.2 one cut domain, family member 1 LOC388122 15 similar to Laminin receptor 1 LOC390585 15 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) LOC388123 15 LOC388123 FLJ38736 15q21.1 hypothetical protein FLJ38736 UNC13C 15q21.1 unc-13 homolog C (C. elegans)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4682 - 352 - 2007 17928307
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain     Homo sapiens
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow    Homo sapiens
Muscularstriatumskeletal   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmegakaryocyte Homo sapiens
Blood/Hematopoieticplatelet Homo sapiens
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal tropomyosin binding domain and
  • a C terminal actin-binding domain, and C-terminal (LRR) domain having roles in the formation of neurite-like processes
  • HOMOLOGY
    interspecies homolog to murineTmod3
    Homologene
    FAMILY tropomodulin family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • localizes to lateral cell membranes in polarized epithelia of several cell types
  • TMOD1, TMOD2 and TMOD3 are associated with the cytoskeleton of non-muscle cells and their expression has distinct consequences on cell morphology
  • basic FUNCTION
  • blocking the elongation and depolymerization of the actin filaments at the pointed end
  • TMOD3-capped tropomyosin-actin filaments provide likely crucial links in the spectrin membrane skeleton of polarized epithelial cells, enabling the membrane skeleton to maintain cell shape
  • TMOD3 and TMOD4 compensate for the absence of TMOD1 structurally but not functionally
  • TMOD1-TMOD3 but not TMOD4 nucleate actin filament assembly
  • is an actin-capping protein that binds to the two tropomyosins (TM) at the pointed end of the actin filament to prevent further actin polymerization and depolymerization
  • is a protein that binds and caps the pointed ends of actin filaments in erythroid and nonerythoid cell types
  • novel function for TMOD3 in regulating actin remodeling or turnover in cells
  • regulation of actin polymerization by TMOD3 controls megakaryocyte actin organization and platelet biogenesis
  • TMOD1, TMOD2, TMOD3 regulates the length of actin filaments by capping the pointed ends in a tropomyosin (TM)-dependent manner
  • cap pointed ends of actin filaments and to be enriched in leading-edge ruffles and lamellipodia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TMOD3 binds actin monomers over an extended interface and nucleating activity depends on actin monomer binding and pointed end-capping activities, contributed by N- and C-terminal domains of TMOD3, respectivelyv
  • TMOD3 is a novel AKT2 effector regulating insulin-stimulated SLC2A4 exocytosis through cortical actin remodeling
  • two actin-related binding partners of PLS3, are CORO1C, and TMOD3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    leads to impaired definitive erythropoiesis due to reduced progenitors, impaired erythroblastic island formation, and defective erythroblast cell-cycle progression and enucleation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum anti-TPM3, anti-TMOD3, anti-STOML2 could be new markers for the early diagnosis of endometriosis
  • Therapy target
    ANIMAL & CELL MODELS