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FLASH GENE
Symbol TMEM9B contributors: mct/npt - updated : 24/09/2008
HGNC name TMEM9 domain family, member B
HGNC id 1168
Location 11p15.3      Physical location : 8.968.839 - 8.985.989
Synonym name chromosome 11 open reading frame 15
Synonym symbol(s) C11orf15
DNA
TYPE functioning gene
STRUCTURE 17.15 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1753 22.5 198 - Clark (2003)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 pancreas exocrine    
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text highly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine 2310004K06 Rik
homolog to Drosophila CG2789
Homologene
FAMILY
  • UPF0196 family
  • TMEM9 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane-associated
    basic FUNCTION
  • signal transducer activity
  • regulates the activity of inflammatory signaling pathways
  • required for the production of proinflammatory cytokines induced by TNF, IL1beta, and TLR ligands but not for apoptotic cell death triggered by TNF or Fas ligand
  • essential in TNF activation of both the NF-kappaB and MAPK pathways
  • key component of inflammatory signaling pathways and endosomal or lysosomal compartments regulate these pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text positive regulation of I-kappaB kinase/NF-kappaB cascade
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS