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FLASH GENE
Symbol TMEM88 contributors: mct - updated : 04-07-2011
HGNC name transmembrane protein 88
HGNC id 32371
Location 17p13.1      Physical location : 7.758.383 - 7.759.415
Synonym name
  • target protein transmembrane 88
  • Synonym symbol(s) FLJ20025, MGC71744
    DNA
    TYPE functioning gene
    STRUCTURE 1.03 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 887 - 159 - 2010 21044957
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately Homo sapiens
    Lymphoid/Immunespleen   moderately Homo sapiens
    Reproductivefemale systemplacenta  highly Homo sapiens
    Urinarykidney   moderately Homo sapiens
    Visualeye   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac moderately Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two-transmembrane domains (AAs 4466 comprise the first transmembrane domain, and AAs 86108 comprise the second)
  • C-terminal VWV (Val-Trp-Val) motif is sufficient to recognize the Dvl PDZ domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may plays a role in regulating Wnt signaling
  • blocks Wnt signaling, presumably by disrupting the Dvl-Fz interaction in cells
  • conditionally modulates Wnt signaling-related gene expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between the PDZ domain of Dvl and the C-terminal tail of TMEM88
  • associates with Dvl proteins and regulates Wnt signaling in a context-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS