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FLASH GENE
Symbol TMEM86B contributors: mct - updated : 23-04-2012
HGNC name transmembrane protein 86B
HGNC id 28449
Location 19q13.42      Physical location : 55.738.002 - 55.740.632
Genatlas name lysoplasmalogenase
Synonym symbol(s) MGC30208
EC.number 3.3.2.5/ 3.3.2.2
DNA
TYPE like-sequence
STRUCTURE 2.63 kb     3 Exon(s)
MAPPING cloned Y linked Y status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1751 24.5 226 - 2011 21515882
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine    Homo sapiens
 liver   predominantly Homo sapiens
Nervousbrain     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • many hydrophobic amino acids
  • six transmembrane domains
  • HOMOLOGY
    Homologene
    FAMILY YhhN family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,microsome
    text located throughout the cytoplasm
    basic FUNCTION
  • catalyzes hydrolytic cleavage of the vinyl ether bond of lysoplasmalogen, forming fatty aldehyde and glycerophosphoethanolamine or glycerophosphocholine
  • may be important in regulating plasmalogen levels in animal cells
  • probably an important enzyme in maintaining the balance between plasmalogen and lysoplasmalogen and thereby preserving membrane stability and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS