Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TMEM63B contributors: mct - updated : 22-11-2019
HGNC name transmembrane protein 63B
HGNC id 17735
Location 6p21.1      Physical location : 44.095.375 - 44.123.255
Synonym name
  • CSC1-like protein 2
  • Synonym symbol(s) c6orf110, DKFZp686N2275
    DNA
    TYPE functioning gene
    STRUCTURE 28.90 kb     24 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 3334 - 832 - 2016 27045885
    24 - 3284 - 832 - 2016 27045885
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils     Homo sapiens
    Reproductivemale systemmale genital tractepididymis   Homo sapiens
    Respiratorylung     Homo sapiens
    Urinarykidney     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • TMEM63B localizes to the plasma membrane and is associated with F-actin
  • basic FUNCTION
  • TMEM63A, TMEM63B, TMEM63C are required to constitute a hyperosmolarity activated ion channel, and may serve as an osmolarity sensitive ion channel for the osmoreception
  • TMEM63A, TMEM63B and TMEM63C might work in concert to constitute a hyperosmolarity activated ion channel
  • role in the cancer in which it is frequently overexpressed
  • promotes [Ca2+]i influx across the plasma membrane in response to extracellular [Ca2+] and hyperosmolarity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential role(s) of TMEM63B as a cancer biomarker
  • Therapy target
    ANIMAL & CELL MODELS