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FLASH GENE
Symbol TMEM50B contributors: mct - updated : 15-03-2011
HGNC name transmembrane protein 50B
HGNC id 1280
Location 21q22.11      Physical location : 34.821.448 - 34.852.281
Synonym name
  • chromosome 21 open reading frame 4
  • HCV p7-transregulated protein 3
    • Synonym symbol(s) C21orf4, HCVP7TP3, UNQ167/PRO193, DKFZp686C2482, FLJ26146
    DNA
    TYPE functioning gene
    STRUCTURE 30.83 kb     7 Exon(s)
    MAPPING cloned Y linked   status provisional
    Map see IFNAR1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 381 - 126 - Tao
    7 - 2350 17.9 158 - 2000 11256614
    EXPRESSION
    Rna function strong mRNA expression was seen in the cerebellum, hippocampus and olfactory bulb, with diffuse cortical expression
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     liver    
    Lymphoid/Immunespleen    
    Nervousbrainhindbraincerebellum   Homo sapiens
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		four potentials transmembrane domains
    HOMOLOGY
    interspecies ortholog to murine Tmem50b
    Homologene
    FAMILY UPF0220 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • integral membrane protein
  • present on endoplasmic reticulum (ER) and Golgi apparatus membranes
    • basic FUNCTION
  • developmentally-regulated intracellular ER and Golgi apparatus membrane protein that may prove important for correct brain development through functions associated with precursor cells and glia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS