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FLASH GENE
Symbol TMEM41A contributors: mct - updated : 14-06-2021
HGNC name transmembrane protein 41A
HGNC id 30544
Location 3q27.2      Physical location : 185.207.388 - 185.216.845
Synonym symbol(s) MGC15397, DKFZp686N06149, DKFZp686N107, 2900010K02Rik
DNA
TYPE functioning gene
STRUCTURE 16.39 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2840 - 264 - 2018 30015937
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunespleen   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • TMEM41 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • TMEM41A may induce autophagy within Gastric cancer (GC) cells
  • may be considered to be an important oncogene in GC
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may participate in the regulation of E-cadherin and N-cadherin expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Gastric cancer (GC), and may be associated with the progression of GC and poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    may be considered as a novel therapeutic target for the treatment of GC‑associated metastasis
    ANIMAL & CELL MODELS