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FLASH GENE
Symbol TMEM30B contributors: mct - updated : 17-01-2015
HGNC name transmembrane protein 30B
HGNC id 27254
Location 14q23.1      Physical location : 61.744.090 - 61.748.530
Synonym name
  • cell cycle control protein 50B
  • Synonym symbol(s) CDC50B, MGC126775
    DNA
    TYPE functioning gene
    STRUCTURE 4.44 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4443 - 351 - 2004 15375526
    EXPRESSION
    Rna function mRNA was expressed in pancreatic islet, kidney, prostate as well as in lung carcinoid, parathyroid tumor, bladder tumor, meningioma and pancreatic cancer
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
    Endocrinepancreas    
     parathyroid    
    Respiratorylung    
     respiratory tracttrachea   
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines in lung carcinoid, parathyroid tumor, bladder tumor, meningioma and pancreatic cancer cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    two-transmembrane- doamins
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • components of phospholipid-translocators
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions of TMEM30A and TMEM30B with multiple members of the human P(4)-ATPase family, suggesting that these proteins perform broader functions in human physiology than thus far assumed
  • ATP8B1 shifted from the endoplasmic reticulum (ER) to the plasma membrane upon coexpression of TMEM30A or TMEM30B
  • TMEM30 is not essential for the ER exit or TGN localization of ATP9B, whereas TMEMA, but not TMEM30B, is required for ER exit and/or recycling endosomal localization of ATP11B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS