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FLASH GENE
Symbol TMEM260 contributors: mct - updated : 10-05-2017
HGNC name chromosome 14 open reading frame 101
HGNC id 20185
Corresponding disease
CRDS cardio-reno-digital syndrome
Location 14q22.3      Physical location : -
Synonym name hypothetical protein LOC54916
Synonym symbol(s) FLJ20392, C14orf101
DNA
TYPE functioning gene
STRUCTURE 80.84 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 4278 87 707 uniform protein distribution throughout the cytoplasm and appreciable localization in the vicinity of the plasma membrane 2017 28318500
  • long isoform
  • - - - 52 409 largely perinuclear 2017 28318500
  • short isoform, truncated
  • truncating mutations that cause CRDS
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C terminus of the protein might confer subcellular localization specificity or indeed a discrete functionality in one of the organellar membranes
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CRDS
    Susceptibility
  • to overall survival in non-Hodgkin lymphoma (NHL)
  • Variant & Polymorphism SNP
  • rs4901706, located in the 3prime UTR of TMEM260, was shown to be independently related to overall survival in non-Hodgkin lymphoma (NHL) patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS