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FLASH GENE
Symbol TMEM243 contributors: mct - updated : 08-12-2020
HGNC name transmembrane protein 243
HGNC id 21707
Location 7q21.12      Physical location : -
Synonym name
  • chromosome 7 open reading frame 23
  • MDR1 and Mitochondrial Taxol Resistance Associated Gene
  • Synonym symbol(s) MGC4175, MM-TRAG, C7orf23
    DNA
    TYPE functioning gene
    STRUCTURE 24.43 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1227 - 118 - 2020 32276105
    5 - 1154 - 118 - 2020 32276105
    5 - 1371 - 118 - 2020 32276105
    4 - 1062 - 118 - 2020 32276105
    5 - 1150 - 118 - 2020 32276105
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryalveolar macrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • may play a role in the development of taxol resistance in human cancer
  • played a role in the regulation of lysosomal-mediated autophagosome, macroautophagy, endosome-to-lysosome transport and iron transmembrane transporters
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Parkinson disease (PD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be a new potential biomarker of PD
  • Therapy target
    ANIMAL & CELL MODELS