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FLASH GENE
Symbol TMEM222 contributors: mct - updated : 18-10-2022
HGNC name transmembrane protein 222
HGNC id 25363
Corresponding disease
NEDMOSBA neurodevelopmental disorder with motor and speech delay and behavioral abnormalities
Location 1p36.11      Physical location : 27.648.635 - 27.662.890
Synonym name chromosome 1 open reading frame 160
Synonym symbol(s) MGC111002, C1orf160, DKFZP564D0478, NEDMOSBA
DNA
TYPE functioning gene
STRUCTURE 14.26 kb     6 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1596 - 208 - 2021 33824500
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumear   highly
Lymphoid/Immunetonsils   highly
Nervousbrainforebraincerebral cortexoccipital cortexhighly Homo sapiens
 brainforebraincerebral cortexparietal cortexhighly Homo sapiens
Reproductivefemale systemovary  moderately
 female systemuteruscervix highly
 male systemprostate  moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately
Connectivebone  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • role for TMEM222 in brain development and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEDMOSBA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS