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FLASH GENE
Symbol TMEM204 contributors: npt/mct - updated : 23-08-2010
HGNC name transmembrane protein 204
HGNC id 14158
Location 16p13.3      Physical location : 1.584.230 - 1.605.243
Synonym name
  • claudin-like protein 24
  • chromosome 16 open reading frame 30
    • Synonym symbol(s) CLP24, FLJ20898, C16orf30, MGC111564
    DNA
    TYPE functioning gene
    STRUCTURE 26.89 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 943 24 226 - Kearsey (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine    
    Lymphoid/Immunethymus   predominantly
    Nervousbrain    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a potential N-glycosylation site
  • four alpha-helical transmembrane domains
  • a C-terminal PDZ domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • novel regulator of KDR and FLT4 signaling pathways and of normal lymphatic vessel structure (Saharinen 2010)
  • modulator of KDR and FLT4 signals required for lymphatic vascular development (Saharinen 2010)
  • has an essential function in the lymphatic vasculature (Saharinen 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with vascular endothelial growth factor receptor-2 KDR and FLT4 and attenuates the transcription factor CREB phosphorylation via these receptors (Saharinen 2010)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS