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FLASH GENE
Symbol TMEM18 contributors: mct/npt - updated : 22-05-2015
HGNC name transmembrane protein 18
HGNC id 25257
Location 2p25.3      Physical location : 667.974 - 677.439
Synonym symbol(s) DKFZp434C1714
DNA
TYPE functioning gene
STRUCTURE 9.47 kb     5 Exon(s)
regulatory sequence Promoter
text structure
  • adipose tissue depot specific TMEM18 promoter methylation that may mediate inter-depot specific variance in TMEM18 mRNA expression
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2138 16.13 140 - 2008 18559506
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain     Homo sapiens
    Reproductivefemale systemuteruscervix  
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure predicted to be mostly alpha-helical with three transmembrane parts
    HOMOLOGY
    Homologene
    FAMILY
  • TMEM18 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • localises to the nuclear membrane and binds to DNA in a sequence-specific manner
  • basic FUNCTION
  • cell migration modulator (Jurvansuu 2008)
  • is involved in both adult and childhood obesity
  • the closed perinuclear localisation of TMEM18-bound DNA might repress transcription from it
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds to DNA in a sequence-specific manner
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    provide neural stem cells and neural precursors an increased migration capacity toward glioblastoma cells (Jurvansuu 2008)
    tumoral     --low  
    resulted in almost complete loss of the migration activity of these cells (Jurvansuu 2008)
    Susceptibility
  • to obesity (Hotta 2009)
  • to T2Diabetes
  • Variant & Polymorphism SNP
  • rs7561317 associated to obesity risk (Hotta 2009)
  • strong association for two SNPs (rs6548238 and rs756131) of the TMEM18 locus with an increased risk for obesity
  • rs7561317 in TMEM18 showed BMI independent association with younger age at diagnosis of T2Diabetes
  • Candidate gene
    Marker
    Therapy target overexpression of this protein could be favorably used in neural stem cells -based glioma therapy (Jurvansuu 2008)
    ANIMAL & CELL MODELS