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FLASH GENE
Symbol TMEM174 contributors: npt/mct - updated : 16-07-2010
HGNC name transmembrane protein 174
HGNC id 28187
Location 5q13.2      Physical location : 72.469.022 - 72.470.968
Synonym symbol(s) MGC13034, FLJ31268
DNA
TYPE functioning gene
STRUCTURE 1.95 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1758 26 243 - Wang (2010)
EXPRESSION
Rna function RNA transcripts are highly expressed in human kidney tissue (Wang 2010)
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two predicted transmembrane helices which determine its subcellular localization, spanning AA regions 3860 and 7092 (Wang 2010)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text subcellular localization of TMEM174 in the endoplasmic reticulum is dependent on the transmembrane helices (Wang 2010)
    basic FUNCTION
  • can play a role in renal development (Wang 2010)
  • may be involved in tissue- or cell-specific function and/or differentiation (Wang 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    could promote the transcriptional activity of AP-1 dependent on its transmembrane helices, which was partly mediated by the ERK pathway (Wang 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS