Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TMEM147 contributors: mct/ - updated : 19-01-2011
HGNC name transmembrane protein 147
HGNC id 30414
Location 19q13.12      Physical location : 36.036.544 - 36.038.428
Synonym name
  • seven transmembrane domain protein
  • protein NIFIE 142 3
  • Synonym symbol(s) NIFIE14, MGC1936
    DNA
    TYPE functioning gene
    STRUCTURE 1.88 kb     7 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 869 22 224 - 2010 20538592
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     intestinesmall intestine  highly
     pancreas exocrine   highly
    Reproductivefemale systemovary  highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • localized to ER membranes
  • basic FUNCTION
  • represents a potent negative regulator of M3R function, most likely by interacting with M3Rs in an intracellular compartment (ER)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • novel core component of the Nicalin-NOMO complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CHRM3 (represents a potent negative regulator of CHRM3 function, most likely by interacting with CHRM3 in an intracellular compartment (ER))
  • major interactor of Nicalin and NOMO
  • IER3IP1, PPIB, EMC7, SPINT2, C14orf1/PEBP28, TMEM147, YIPF6, and KRTCAP2 interacting with SLC41A1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS