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FLASH GENE
Symbol TMEM132D contributors: mct - updated : 29-03-2022
HGNC name transmembrane protein 132D
HGNC id 29411
Location 12q24.33      Physical location : 129.556.270 - 130.388.212
Synonym name
  • mature oligodendrocyte transmembrane protein
  • KIAA1944 protein
  • mature OL transmembrane protein
  • hypothetical protein LOC121256
    • Synonym symbol(s) MOLT, KIAA1944, HBE120, MGC138770, MGC138771, PPP1R153
    DNA
    TYPE functioning gene
    STRUCTURE 831.94 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 5777 122 1099 - 2003 12966072
    EXPRESSION
    Rna function higher TMEM132D mRNA expression levels in the frontal cortex
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratorylung    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a transmembrane domain
  • extra-cellular portions contain five conserved domains including three tandem immunoglobulin domains, and a cohesin domain homologue
    • HOMOLOGY
    interspecies ortholog to C. elegans gene Y71H2AM.10
    Homologene
    FAMILY
  • TMEM132 family
    • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • may function as oligodendrocytes become mature and may serve as a cell-surface marker for oligodendrocytes differentiation
  • potential cellular adhesion function for TMEM132 family, connecting the extracellular medium with the intracellular actin cytoskeleton
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCKAP1 binds to TMEM132D
  • TMEM132A, TMEM132B, TMEM132C, TMEM132D may regulate NCKAP1 in WAVE regulatory complex (WRC) to finely modulate actin nucleation, cellular cytoskeletal and morphological changes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in frontotemporal dementia (FTD)
    constitutional       loss of function
    may thus lead to abnormal neuronal structure and dynamics, contributing to heightened risks for depression, anxiety and panic disorders (
    Susceptibility to panic disorder (PD)
    Variant & Polymorphism other
  • rs7370927 and rs11060369 associated with panic disorder (PD)
    • Candidate gene may thus be an important new candidate gene for Panic disorder as well as more generally for anxiety-related behavior
    Marker
    Therapy target
    ANIMAL & CELL MODELS