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FLASH GENE

Symbol

TMEM132A

contributors: mct - updated : 29-03-2022

HGNC name	transmembrane protein 132A
HGNC id	31092

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q12.2      Physical location : 60.691.912 - 60.704.630
Synonym name	likely ortholog of rat GRP78-binding protein
	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) binding protein 1
	glucose-regulated protein, 78kDa
	transmembrane protein 132A, isoform b
Synonym symbol(s)	FLJ20539 , GBP, HSPA5BP1, MGC138669, DKFZp547E212

DNA

TYPE	functioning gene
STRUCTURE	12.00 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed GBP variant 1 - - 3520 - 1024 - Oh-Bashi GBP variant 2 - - 3517 110 1023 - Oh-Bashi

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Endocrine pancreas         Nervous brain diencephalon hypothalamus     Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

extra-cellular portions contain five conserved domains including three tandem immunoglobulin domains, and a cohesin domain homologue

HOMOLOGY

interspecies	ortholog to TMEM132A TMEM132A
	ortholog to murine Tmem132a

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION

playing a functional role in embryonic and postnatal development of the brain

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

TMEM132A, TMEM132B, TMEM132C, TMEM132D may regulate NCKAP1 in WAVE regulatory complex (WRC) to finely modulate actin nucleation, cellular cytoskeletal and morphological changes

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS