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FLASH GENE
Symbol TMEM121 contributors: - updated : 26-03-2007
HGNC name transmembrane protein 121
HGNC id 20511
Corresponding disease
DEL14QD chromosome 14q terminal deletion
Location 14q32.33      Physical location : 105.992.952 - 105.996.539
Synonym name hole protein
Synonym symbol(s) MGC4659, hole
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Nervousbrain   highly
Reproductivefemale systembreastmammary gland highly
 male systemprostate  highly
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
Text heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal ERK binding domains (D-domains)
  • proline-rich C-terminal motifs
  • six-transmembrane domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION may interact with SH3-domain proteins or ERKs to mediate signaling pathways/networks that lead to the suppression of AP-1 and SRE
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL14QD
    Susceptibility
    Variant & Polymorphism
    Candidate gene for ID in del 14qter
    Marker
    Therapy target
    ANIMAL & CELL MODELS