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FLASH GENE

Symbol

TMEM102

contributors: mct - updated : 24-06-2016

HGNC name	transmembrane protein 102
HGNC id	26722

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13.1      Physical location : 7.338.761 - 7.340.998
Synonym name	common beta-chain associated protein
Synonym symbol(s)	CBAP, FLJ36878

DNA

TYPE	functioning gene
STRUCTURE	2.24 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_178518 3 - 1996 NP_848613 54 508 - 2013 23620790 NM_001320444 2 - 2099 NP_001307373 - 508 - 2013 23620790

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       moderately Endocrine adrenal gland       highly Reproductive female system uterus cervix   moderately Respiratory respiratory tract larynx     moderately

cell lineage
cell lines
fluid/secretion	predominantly in lymph and moderately in blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus Tmem102 (78.9 pc)
	homolog to murine Tmem102 (79.7 pc)

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
text	single-pass membrane protein

basic FUNCTION	modulating GM-CSF-deprivation-induced apoptosis possibly via a novel mechanism involving interaction with an un-liganded betac molecule
	is a novel component in the TCR signaling pathway and modulates thymocyte apoptosis during negative selection

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

indeed can function as a novel signaling component within the ZAP70/VAV1/talin complex and plays an important role in regulating chemokine-promoted T-cell trafficking (23620790)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Cbap-deficient mice showed normal early thymocyte development and positive selection