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FLASH GENE
Symbol TMED4 contributors: KTN/npt - updated : 18/11/2008
HGNC name transmembrane emp24 protein transport domain containing 4
HGNC id 22301
Location 7p13      Physical location : 44.618.762 - 44.621.827
Synonym name
  • putative NFkB activating protein HNLF
  • endoplasmic reticulum stress-response protein 25
  • Synonym symbol(s) HNLF, ERS25
    DNA
    TYPE functioning gene
    STRUCTURE 3.07 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1048 25.8 227 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   moderately
     liver    
    Endocrineparathyroid   predominantly
    Hearing/Equilibriumear   highly
    Reproductivefemale systemplacenta  moderately
     female systemuteruscervix highly
     male systemprostate   
    Respiratorylung   moderately
    Skin/Tegumentskin   moderately
    Urinarybladder   highly
     kidney   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion moderately in blood
    at STAGE
    physiological period embryo, pregnancy
    Text kidney, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 29 aa signal peptide
  • one gold (Golgi dynamics) domain
  • a coiled-coil region
  • a transmembrane domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog TMED4 (96.3 pc)
    homolog to chimpanzee TMED4 (99.6 pc)
    homolog to cow TMED4 (94.3 pc)
    homolog to rattus Tmed4 (94.7 pc)
    homolog to murine Tmed4 (94.7 pc)
    Homologene
    FAMILY
  • EMP24/GP25L family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus
    text single-pass type I membrane protein
    basic FUNCTION
  • involved in vesicular protein trafficking between the ER and the Golgi
  • involved in the positive regulation of I-kappaB kinase/NF-kappaB cascade
  • may play a critical role in regulation of heat-shock response and apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    I-kappaB kinase/NF-kappaB cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by ER-specific stress, heat shock, and oxidative stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS