SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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text
| AIM1, ERGIC1 and TMED3 were co-expressed in the set of genes functionally annotated to ER and Golgi apparatus and redox reactions |
basic FUNCTION
| is a constituent of the coated vesicles that are involved in the transportation of cargo molecules from the ER to the Golgi complex and function as receptors for specific secretory cargo |
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involved in bidirectional cargo trafficking from the rough endoplasmic reticulum through the Golgi and into secretory vesicles |
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high AIM1 and TMED3 expression associates with genes involved in lipid metabolism, and high ERGIC1 and TMED3 expression with genes involved in redox homeostasis |
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ERGIC1 and TMED3 expression associated with ER and Golgi apparatus function |
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TMED3 and SOX12 belong to different families involved in protein secretion and transcriptional regulation, but both promote endogenous WNT-TCF activity |
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TMED3 and SOX12 are required for efficient clonogenic behavior but only TMED3 for clone compaction |
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TMED3 is required for normal WNT localization, and TMED3 function is required for normal intracellular localization of WNT ligands |
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TMED3 and SOX12 have novel metastatic suppressive functions in human colon cancer cells |