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FLASH GENE
Symbol TMED3 contributors: mct - updated : 22-12-2017
HGNC name transmembrane p24 trafficking protein 3
HGNC id 28889
Location 15q25.1      Physical location : 79.603.490 - 79.615.188
Synonym symbol(s) p26, P24B, C15orf22
DNA
TYPE functioning gene
STRUCTURE 73.66 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2370 - 155 - 2014 24920608
3 - 1495 - 217 - 2014 24920608
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY family of p24 proteins
CATEGORY receptor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
text
  • AIM1, ERGIC1 and TMED3 were co-expressed in the set of genes functionally annotated to ER and Golgi apparatus and redox reactions
  • basic FUNCTION
  • is a constituent of the coated vesicles that are involved in the transportation of cargo molecules from the ER to the Golgi complex and function as receptors for specific secretory cargo
  • involved in bidirectional cargo trafficking from the rough endoplasmic reticulum through the Golgi and into secretory vesicles
  • high AIM1 and TMED3 expression associates with genes involved in lipid metabolism, and high ERGIC1 and TMED3 expression with genes involved in redox homeostasis
  • ERGIC1 and TMED3 expression associated with ER and Golgi apparatus function
  • TMED3 and SOX12 belong to different families involved in protein secretion and transcriptional regulation, but both promote endogenous WNT-TCF activity
  • TMED3 and SOX12 are required for efficient clonogenic behavior but only TMED3 for clone compaction
  • TMED3 is required for normal WNT localization, and TMED3 function is required for normal intracellular localization of WNT ligands
  • TMED3 and SOX12 have novel metastatic suppressive functions in human colon cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RPS15A was determined as a potential downstream target for TMED3 involved in the progression of osteosarcoma
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer samples
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    induction of apoptosis due to AIM1 and TMED3 inhibition especially in the androgen independent prostate cancer cells
    cancerbone 
    importance of TMED3/RPS15A axis in promoting tumor progression, which may be a promising candidate for molecular therapy of osteosarcoma.
    ANIMAL & CELL MODELS