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FLASH GENE

Symbol

TMED2

contributors: npt - updated : 07-07-2005

HGNC name	transmembrane emp24 domain trafficking protein 2
HGNC id	16996

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q24.31      Physical location : 124.069.075 - 124.082.681
Synonym name	coated vesicle membrane protein
	membrane protein p24A
Synonym symbol(s)	P24A, RNP24, FLJ21323

DNA

TYPE	functioning gene
STRUCTURE	13.00 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed TMED2 4 - 2126 22 201 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     predominantly   liver       moderately   pancreas exocrine       moderately Reproductive female system uterus     moderately   female system ovary     moderately   female system breast mammary gland   moderately   male system prostate     moderately Skin/Tegument skin       moderately Urinary bladder       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a GOLD domain

HOMOLOGY

interspecies

ortholog to rattus Rnp24

Homologene

FAMILY

EMP24/GP25L family

CATEGORY

regulatory , transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic,microsome
text	type I membrane protein
	Golgi-derived coatomer-coated vesicles

basic FUNCTION	could have a role in the budding of coatomer-coated and other species of coated vesicles
	could bind cargo molecules to collect them into budding vesicles
	inhibiting the GTPase-activating activity of ARFGAP1
	involved in vesicular targeting

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	intracellular protein transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ARFGAP1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS