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FLASH GENE
Symbol TMED2 contributors: npt - updated : 07-07-2005
HGNC name transmembrane emp24 domain trafficking protein 2
HGNC id 16996
Location 12q24.31      Physical location : 124.069.075 - 124.082.681
Synonym name
  • coated vesicle membrane protein
  • membrane protein p24A
  • Synonym symbol(s) P24A, RNP24, FLJ21323
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2126 22 201 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  predominantly
     liver   moderately
     pancreas exocrine   moderately
    Reproductivefemale systemuterus  moderately
     female systemovary  moderately
     female systembreastmammary gland moderately
     male systemprostate  moderately
    Skin/Tegumentskin   moderately
    Urinarybladder   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GOLD domain
  • HOMOLOGY
    interspecies ortholog to rattus Rnp24
    Homologene
    FAMILY
  • EMP24/GP25L family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,microsome
    text
  • type I membrane protein
  • Golgi-derived coatomer-coated vesicles
  • basic FUNCTION
  • could have a role in the budding of coatomer-coated and other species of coated vesicles
  • could bind cargo molecules to collect them into budding vesicles
  • inhibiting the GTPase-activating activity of ARFGAP1
  • involved in vesicular targeting
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • intracellular protein transport
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARFGAP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS