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FLASH GENE
Symbol TMED10 contributors: mct - updated : 23-02-2010
HGNC name transmembrane emp24-like trafficking protein 10 (yeast)
HGNC id 16998
Location 14q24.3      Physical location : 75.598.170 - 75.643.349
Synonym name
  • 21kDa transmembrane trafficking protein
  • multimeric protein with a serine protease domain
  • Synonym symbol(s) P24(DELTA), S31III125, S31I125, TMP21, TMP21-I, p23 TMP21
    DNA
    TYPE functioning gene
    STRUCTURE 45.18 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4163 23 219 - 2009 19710022
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Nervousnerve    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text in the brain is high during embryonic development and then declines after birth
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a serine protease domain
  • a scavenger cysteine-rich domain
  • a LDL receptor class A domain
  • a GOLD domain
  • a transmembrane domain promoting its association with the presenilin complex that results in decreased gamma-cleavage activity
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Emp24p
    homolog to murine Tmed10 (92.2pc)
    homolog to rattus TMP21 (92.7pc)
    Homologene
    FAMILY
  • EMP24/GP25L family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,microsome
    text type I membrane protein; golgi cisternae
    basic FUNCTION
  • involved in vescular protein trafficking
  • differentially regulating gamma-secretase cleavage without affecting epsilon-secretase activity
  • transmembrane protein involved in endoplasmic reticulum/Golgi transpor
  • member of the p24 cargo-protein family that is involved in vesicular targeting and protein transport
  • presenilin complex component that modulates gamma- but not epsilon-secretase activities
  • behaves as a regulator of gamma- but not epsilon-cleavages generated by presenilin-dependent gamma-secretase complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of presenilin complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with gamma-secretase, and negatively regulates beta-amyloid production
  • interact with presenilin complexes
  • cell & other
    REGULATION
    Other degradation of TMED10, as with the other presenilin-associated gamma-secretase complex members, is mediated by the ubiquitin-proteasome pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in the brains of individuals with AD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    ability of the TMED10 peptide to alter APP processing and Abeta production could represent a novel strategy for modulating amyloid production and its subsequent pathology
    ANIMAL & CELL MODELS