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FLASH GENE
Symbol TMED1 contributors: mct - updated : 22-08-2014
HGNC name transmembrane emp24 protein transport domain containing 1
HGNC id 17291
Location 19p13.2      Physical location : 10.943.115 - 10.946.983
Synonym name
  • putative T1/ST2 receptor binding protein
  • interleukin 1 receptor-like 1 ligand
  • IL1RL1-binding protein
  • p24 family protein gamma-1
  • Synonym symbol(s) IL1RL1LG, MGC1270, ST2L, MGC1270, IL1RL1L
    DNA
    TYPE functioning gene
    STRUCTURE 4.24 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1739 25 227 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus   highly
    Cardiovascularheart    
    Endocrinepancreas   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal extracytoplasmic region
  • a transmembrane domain
  • a GOLD domain
  • a short cytoplasmic tail
  • HOMOLOGY
    interspecies ortholog to murine Il1rl1l
    homolog to Drosophila CG9053
    Homologene
    FAMILY
  • EMP24/GP25L family
  • CATEGORY receptor membrane , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text type I transmembrane protein
    basic FUNCTION
  • leading to the activation of DNA binding by nuclear factor kappa-B (NFKB) or transcription from the IL8 promoter
  • TMED1 is required for optimal IL33-induced IL8 and IL6 production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to interleukin 1 receptor-like 1 (IL1RL1)
  • TMED1 associates with IL1RL1 (interaction mediated by the GOLD domain of TMED1 and the TIR domain of IL1RL1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS