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FLASH GENE
Symbol TMC6 contributors: mct/npt - updated : 13-01-2009
HGNC name transmembrane channel-like 6
HGNC id 18021
Corresponding disease
EV1 epidermodysplasia verruciformis, protein 1 and 2
Location 17q25.3      Physical location : 76.108.998 - 76.128.488
Synonym name
  • epidermodysplasia verruciformis 1
  • expressed in activated T/LAK lymphocytes
  • transmembrane channel-like 6
  • protein LAK-4
    • Synonym symbol(s) EVIN1, EV1-LAK4P, EVER1, FLJ17776, LAK-4P, EV1
    DNA
    TYPE functioning gene
    STRUCTURE 19.49 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2815 90 805 - Ramoz, Olsen (2006)
    20 splicing 2789 - 805 - Ramoz, Olsen (2006)
    lack exons 11-18
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text cord blood
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two leucine zipper motifs
  • ten transmembrane domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Ever1
    homolog to chimpanzee LOC454916
    homolog to chicken tmc6
    intraspecies homolog to TMC8
    Homologene
    FAMILY
  • leukocytes TMC (transmembrane channel-like gene) family
    • CATEGORY receptor membrane , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC30A1 (with TMC8, form a complex and interact with the zinc transporter 1, SLC30A1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EV1
    Susceptibility susceptibility to infection with certain papillomaviruses and high risk of skin carcinoma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS