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FLASH GENE
Symbol TMC2 contributors: mct - updated : 12-12-2017
HGNC name transmembrane channel-like 2
HGNC id 16527
Location 20p13      Physical location : 2.517.252 - 2.622.430
Synonym name
  • chromosome 20 open reading frame 145
  • transmembrane cochlear-expressed protein 2
    • Synonym symbol(s) C20orf145, dJ686C3.3
    DNA
    TYPE functioning gene
    STRUCTURE 105.18 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3169 - 906 - Kurima (2003)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text cochlea,placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Tmc2
    ortholog to zebrafish Tmc2a
    intraspecies homolog to TMC1
    Homologene
    FAMILY
  • TMC family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be crucial for normal auditory function
  • LHFPL5, TMIE, TMC1, and TMC2 have so far been linked to the transduction channel
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PCDH15 interacts with transmembrane channel-like proteins TMC1 and TMC2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS