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FLASH GENE
Symbol TMC2 contributors: mct - updated : 12-12-2017
HGNC name transmembrane channel-like 2
HGNC id 16527
Location 20p13      Physical location : 2.517.252 - 2.622.430
Synonym name
  • chromosome 20 open reading frame 145
  • transmembrane cochlear-expressed protein 2
  • Synonym symbol(s) C20orf145, dJ686C3.3
    DNA
    TYPE functioning gene
    STRUCTURE 105.18 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PTPNS1 20p13 protein tyrosine phosphatase, non-receptor type substrate 1 PDYN 20p13 prodynorphin RPL7P2 20p13 ribosomal protein L7 pseudogene 2 STK35 20 serine/threonine kinase 35 LOC388780 20 LOC388780 TGM3 20p13 transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase) TGM6 20p13 transglutaminase y SNRPB 20p13 small nuclear ribonucleoprotein polypeptides B and B1 MGC10715 20p13 novel C2H2 type zinc finger protein TMC2 20p13 transmembrane, cochlear expressed, 2 NOL5A 20p13 nucleolar protein 5A (56kDa with KKE/D repeat) IDH3B 20p13 isocitrate dehydrogenase 3 (NAD+) beta KIAA1442 20p13 KIAA1442 protein RPL19P1 20p13 ribosomal protein L19 pseudogene 1 CPXM 20p12.3-p13 carboxypeptidase X (M14 family) C20orf141 20p13 chromosome 20 open reading frame 141 LOC388781 20 similar to RIKEN cDNA 4933425O20 C20orf81 20p13 chromosome 20 open reading frame 81 VPS16 20p13-p12 vacuolar protein sorting 16 (yeast) PTPRA 20p13 protein tyrosine phosphatase, receptor type, A GNRH2 20p13 gonadotropin-releasing hormone 2 MRPS26 20p13 mitochondrial ribosomal protein S26 OXT 20p13 oxytocin, prepro- (neurophysin I) AVP 20p13 arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) UBCE7IP5 20p13 likely ortholog of mouse ubiquitin conjugating enzyme 7 interacting protein 5 FLJ13149 20p13 hypothetical protein FLJ13149 ProSAPiP1 20p13 ProSAPiP1 protein C20orf116 20p13 chromosome 20 open reading frame 116 ITPA 20p inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3169 - 906 - Kurima (2003)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text cochlea,placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Tmc2
    ortholog to zebrafish Tmc2a
    intraspecies homolog to TMC1
    Homologene
    FAMILY
  • TMC family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be crucial for normal auditory function
  • LHFPL5, TMIE, TMC1, and TMC2 have so far been linked to the transduction channel
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PCDH15 interacts with transmembrane channel-like proteins TMC1 and TMC2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS