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FLASH GENE
Symbol TMBIM4 contributors: mct - updated : 12-07-2016
HGNC name transmembrane BAX inhibitor motif containing 4
HGNC id 24257
Location 12q14.3      Physical location : 66.530.717 - 66.563.807
Synonym name
  • CGI-119 protein
  • S1R protein
  • Z-protein
  • protein lifeguard 4
  • Golgi anti-apoptotic protein
  • Synonym symbol(s) CGI-119, ZPRO, S1R, LFG4, GAAP
    DNA
    TYPE functioning gene
    STRUCTURE 33.14 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1831 - 238 - 2015 25764978
    7 - 1843 - 162 - 2015 25764978
    7 - 1840 - 207 - 2015 25764978
    8 - 2019 - 285 - 2015 25764978
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestivepancreas exocrine   highly
    Reproductivefemale systemplacenta  moderately
     male systemtestis  highly
    Urinarykidney   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop
  • possess the di-aspartyl pH sensor responsible for pH sensing identified in TMBIM6 8)
  • a common structure of at least seven transmembrane domains with the last domain being semi-hydrophobic
  • HOMOLOGY
    interspecies homolog to murine Tmbim4
    Homologene
    FAMILY
  • TMBIM family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • localized in the endoplasmic reticulum
  • Golgi membrane protein
  • basic FUNCTION
  • represent regulators of cell death pathways (Zhou 2008)
  • play a role in apoptosis
  • is a regulator of intracellular Ca2+ fluxes and apoptosis
  • can oligomerize in a pH-regulated manner, and monomeric TMBIM4 is functional
  • increased cell adhesion, spreading, and migration in a manner that depended on its C-terminal domain
  • Golgi antiapoptotic proteins (GAAP) are highly conserved Golgi membrane proteins that inhibit apoptosis and promote Ca(2+) release from intracellular stores
  • is a novel regulator of focal adhesion dynamics, cell adhesion, and migration by controlling localized Ca(2+)-dependent activation of calpain
  • reduce the CaČ&
  • 8314; content of the endoplasmic reticulum, and all but TMBIM5 also reduce the cytosolic resting CaČ&
    8314; concentration
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • oligomerization of TMBIM4 is independent of cysteines
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS