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FLASH GENE
Symbol TMBIM1 contributors: mct - updated : 01-06-2016
HGNC name transmembrane BAX inhibitor motif containing 1
HGNC id 23410
Location 2q35      Physical location : 219.138.916 - 219.157.280
Synonym symbol(s) PP1201, LFG3, MST100, MSTP100, RECS1
DNA
TYPE functioning gene
STRUCTURE 18.36 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2375 - 311 - 2004 15278903
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • possess the di-aspartyl pH sensor responsible for pH sensing identified in TMBIM6 8)
  • a common structure of at least seven transmembrane domains with the last domain being semi-hydrophobic
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • localized in the Golgi apparatus (TMBIM1-3)
  • basic FUNCTION
  • play a role in apoptosis
  • negatively regulates aortic MMP9 production, and plays protective roles in vascular remodeling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS