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FLASH GENE
Symbol TM4SF4 contributors: mct - updated : 09-05-2012
HGNC name transmembrane 4 L six family member 4
HGNC id 11856
Location 3q25.1      Physical location : 149.192.433 - 149.221.068
Synonym name
  • intestine and liver tetraspan membrane protein
  • Synonym symbol(s) ILTMP, il-TMP, FLJ31015
    DNA
    TYPE functioning gene
    STRUCTURE 28.81 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text using alternate polyadenylation sites
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1624 - 202 - 2001 11267677
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately Homo sapiens
     intestinesmall intestinejejunum   Homo sapiens
     liver   highly Homo sapiens
     pancreas exocrine   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic Hydrophobic
    STRUCTURE
    motifs/domains
  • four potential hydrophobic transmembrane domains
  • a hydrophilic region between domains 3 and 4 containing 2 potential N-linked glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Tm4sf4
    ortholog to murine Tm4sf4
    homolog to xenopus tm4sf4-prov1
    Homologene
    FAMILY
  • L6 domain tetraspanin family
  • tetraspanin (TM4SF) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in negative the regulation of cell proliferation
  • regulating the adhesive and proliferative status of intestinal epithelial cells
  • can mediate density-dependent cell proliferation
  • potential role during endocrine differentiation
  • plays a crucial role in promotion of cancer cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component N-linked glycosylation (required for the growth inhibitory effect)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transcriptional target of NKX2-2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker potential to be biomarker in HCC
    Therapy target
    ANIMAL & CELL MODELS