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FLASH GENE
Symbol TM4SF1 contributors: - updated : 11-06-2007
HGNC name transmembrane 4 superfamily member 1
HGNC id 11853
Location 3q21-q25      Physical location : 149.086.804 - 149.095.568
Synonym name
  • tumor-associated antigen L6
  • membrane component, chromosome 3, surface marker 1
  • Synonym symbol(s) M3S1,TAAL6,T4S1,L6,H-L6
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391586 3 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 LOC344741 3q24 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC389159 3 LOC389159 RPL38P1 3q21-q25 ribosomal protein L38 pseudogene 1 AGTR1 3q21-q25 angiotensin II receptor, type 1 CPB1 7p14-p13 carboxypeptidase B1 (tissue) CPA3 3q21-q25 carboxypeptidase A3 (mast cell) LOC285329 3q24 similar to Ataxin-1 ubiquitin-like interacting protein GYG 3q24 glycogenin SMARCA3 3q25.1-q26.1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 HPS3 3q24-q25.1 Hermansky-Pudlak syndrome 3 CP 3q23-q25 ceruloplasmin (ferroxidase) LOC389160 3 LOC389160 LOC116441 3q24 hypothetical protein BC014339 TM4SF1 3q21-q25 transmembrane 4 superfamily member 1 TM4SF4 3q25 transmembrane 4 superfamily member 4 TAZ Xq28 tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) LOC51122 3q25.1 HSPC042 protein LOC389161 3 hypothetical gene supported by AK027233 LOC389162 3 LOC389162 LOC389163 3 hypothetical gene supported by AK098078 RNF13 3q25.1 ring finger protein 13 PFN2 3q25.1-q25.2 profilin 2 LOC389164 3 similar to Chromosome 1 open reading frame 37 LOC391587 3 similar to peptidyl-Pro cis trans isomerase LOC389165 3 hypothetical gene supported by AF090923; AK023388; BC002719 LOC389166 3 LOC389166 KIAA0669 3q25.1-q25.2 LOC389166 SERP1 3q25.1 stress-associated endoplasmic reticulum protein 1 eIF2A 3q25.1 eukaryotic translation initiation factor (eIF) 2A SELT 3q25.1 selenoprotein T MGC39662 3q25.1 hypothetical protein MGC39662 LOC391588 3 similar to U1 small nuclear ribonucleoprotein C (U1-C) SIAH2 3q25 seven in absentia homolog 2 (Drosophila) LOC389167 3 LOC389167 USH3A 3q21-q25 Usher syndrome 3A TRALPUSH 3q25.1 TRALPUSH H963 3q25.1 TRALPUSH
    RNA
    TRANSCRIPTS type messenger
    text use of alternate polyadenylation sites
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Reproductivefemale systembreast   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines lung,ovarian ,breast, colon carcinoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
    three predicted NH2-terminal hydrophobic transmembrane regions which were followed by a hydrophilic region containing two potential N-linked glycosylation sites and a COOH-terminal hydrophobic transmembrane region
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Tm4sf1
    homolog to C.elegans C09F12.1
    Homologene
    FAMILY
  • tetraspanin family (TM4SF)
  • transmembrane 4 superfamily
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION mediating signal transduction events that play a role in the regulation of cell development,activation,growth and motility
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component present in high molecular weight complexes in tumor cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS