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FLASH GENE
Symbol TM4SF1 contributors: - updated : 11-06-2007
HGNC name transmembrane 4 superfamily member 1
HGNC id 11853
Location 3q21-q25      Physical location : 149.086.804 - 149.095.568
Synonym name
  • tumor-associated antigen L6
  • membrane component, chromosome 3, surface marker 1
  • Synonym symbol(s) M3S1,TAAL6,T4S1,L6,H-L6
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text use of alternate polyadenylation sites
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Reproductivefemale systembreast   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines lung,ovarian ,breast, colon carcinoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
    three predicted NH2-terminal hydrophobic transmembrane regions which were followed by a hydrophilic region containing two potential N-linked glycosylation sites and a COOH-terminal hydrophobic transmembrane region
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Tm4sf1
    homolog to C.elegans C09F12.1
    Homologene
    FAMILY
  • tetraspanin family (TM4SF)
  • transmembrane 4 superfamily
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION mediating signal transduction events that play a role in the regulation of cell development,activation,growth and motility
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component present in high molecular weight complexes in tumor cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS