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FLASH GENE
Symbol TM2D3 contributors: - updated : 18-07-2005
HGNC name TM2 domain containing 3
HGNC id 24128
Location 15q26.3      Physical location : 102.182.053 - 102.192.594
Synonym name
  • BBP-like protein 2
  • Synonym symbol(s) BLP2
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text
  • multiple polyadenylation sites
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1410 27 247 - Kajkowski
    - splicing 1332 24 221 - kajkowski
  • lacking an exon within the coding region, but maintaining the same reading frame compared to variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Lymphoid/Immunelymph node   moderately
    Nervousbrain   predominantly
    Reproductivefemale systemplacenta  highly
     female systemuterus  highly
     female systemovary  moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily
  • HOMOLOGY
    intraspecies homolog to the beta-amyloid binding protein (BBP) (sequence and structural similarities)
    paralog to TM2D2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may have regulatory roles in cell death or proliferation signal cascades
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS