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FLASH GENE
Symbol TLX3 contributors: mct/npt - updated : 21-02-2017
HGNC name T-cell leukemia homeobox 3
HGNC id 13532
Corresponding disease
TALL T-cell acute lymphoblastic leukemia, TLX3 rearranged
Location 5q35.1      Physical location : 170.736.287 - 170.739.137
Synonym name
  • murine respiratory neuron homeobox homolog
  • homeo box 11-like 2
    • Synonym symbol(s) RNX, HOX11L2, MGC29804
    DNA
    TYPE functioning gene
    STRUCTURE 2.85 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1513 31.9 291 - Nagel (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • homeobox domain
    • HOMOLOGY
    interspecies homolog to murine respiratory neuron homeobox
    intraspecies homolog to HOX 11
    Homologene
    FAMILY
  • homeodomain family of DNA binding protein
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the development of the ventral medullary respiratory center
  • able to first induce a set of proneural genes, followed by activation of neural subtype-specific genes
  • exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells
  • functions as the master neuronal fate regulator by instructively promoting the specification of glutamatergic excitatory neurons and suppressing the specification of gamma-aminobutyric acid (GABAergic) neurons
  • promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CREBBP
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS respiration
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TLX3 directly interacts with the epigenetic co-activator cyclic adenosine monophosphate CREBBP and its homeodomain is essential for this interaction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TALL
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with BCL11B, in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia
    tumoral fusion      
    with CDK6 in t(5;7)(q35;q21), and RANBP17 in T-ALL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS