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FLASH GENE
Symbol TLX2 contributors: mct - updated : 10-12-2014
HGNC name T-cell leukemia, homeobox 2
HGNC id 5057
Location 2p13.1-p12      Physical location : 74.741.595 - 74.744.275
Synonym name homeo box 11-like 1
Synonym symbol(s) HOX11L1, NCX, ENX
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D2S2088 - TLX2 - D2S2497 - cen
Authors Puliti (99)
Physical map
MTHFD2 2p12 methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase SLC4A5 2p13 solute carrier family 4, sodium bicarbonate cotransporter, member 5 DCTN1 2p13 dynactin 1 (p150, glued homolog, Drosophila) LOC388963 2 similar to Retinol dehydrogenase 12 LOC257200 2p13.1 similar to high mobility group AT-hook 1 FLJ12953 2p13.1 hypothetical protein FLJ12953 similar to Mus musculus D3Mm3e RTKN 2p13 rhotekin HMGA1L4 2p13.1 high mobility group AT-hook 1-like 4 WBP1 2p12 WW domain binding protein 1 GCS1 2p13 WW domain binding protein 1 MRPL53 2p13.1 mitochondrial ribosomal protein L53 LOC151534 2p13.1 hypothetical protein BC009264 FLJ14397 2p13.1 hypothetical protein FLJ14397 FLJ12788 2p13.1 hypothetical protein FLJ12788 NSPC1 2p13.1 likely ortholog of mouse nervous system polycomb 1 TLX2 2p13.1-p12 T-cell leukemia, homeobox 2 DQX1 2p12 T-cell leukemia, homeobox 2 AUP1 2p13 ancient ubiquitous protein 1 PRSS25 2p13.3 protease, serine, 25 LOXL3 2p13.3 lysyl oxidase-like 3 DOK1 2p13 docking protein 1, 62kDa (downstream of tyrosine kinase 1) LOC130951 2p13.1 hypothetical protein BC014602 SEMA4F 2p13 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
Nervousbrain    
Reproductivemale systemprostate   
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix, DNA binding domain
HOMOLOGY
interspecies homolog to murine tlx1
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • involved in peripheral nervous system development (i.e enteric ganglia), and in the development of correct intestinal innervation
  • transcription factors crucial in the development of neural-crest-derived cells, leading to ANS (autonomic nervous system) specific neuronal lineages
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transcriptional target of PHOX2A, PHOX2B
  • TRPM5 activation by ATP couples TRPM5-mediated Na(+) entry to promote Ca(2+) uptake via a TLX2 to trigger MUC5AC secretion
  • cell & other
    REGULATION
    Other regulated by PHOX2A, PHOX2B, in cells of neural origin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    predicts outcome of gastrointestinal stromal tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS