basic FUNCTION
| pathogen recognition and activation of innate immunity |
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activating an NF-kappa B signaling pathway |
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potential inducer of apoptosis and septic shock |
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could play a critical role in controlling immune responses to cancer and other diseases |
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involved in detection of virus |
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acting as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus |
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play essential roles in generating innate immune responses, and are evolutionarily conserved across species  |
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role for TLR8 as a suppressor of neurite outgrowth as well as an inducer of neuronal apoptosis, and found that TLR8 functions in neurons through an NF-kappaB-independent mechanism  |
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implicated in the sequence-dependent detection of RNA oligonucleotides in immune cells  |
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may confer susceptibility to asthma and related atopic disorders  |
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having functions in the nervous system that are distinct from the classical role of TLRs in immunity |
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its activation may be an important, novel pathway for targeted treatment of Th1-mediated diseases, such as Crohn disease  |
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with TLR7, activate similar signaling pathways that play different roles in dendritic cells maturation, depending on which TLR is triggered  |
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mediates anti-viral immunity by recognizing ssRNA viruses, and triggers potent anti-viral and antitumor immune responses upon ligation by synthetic small molecular weight ligands  |
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TLR7 and TLR8 on trophoblastic cells play an important role in the prevention of intrauterine HBV transmission by inhibiting HBV translocation across trophoblast  |