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FLASH GENE
Symbol TLR6 contributors: mct/npt - updated : 11-02-2013
HGNC name toll-like receptor 6
HGNC id 16711
Location 4p14      Physical location : 38.825.335 - 38.858.437
Synonym name
  • Drosophila transmembrane receptor Toll homolog 6
  • CD286 antigen
  • Synonym symbol(s) CD286
    DNA
    TYPE functioning gene
    STRUCTURE 2.75 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1239 4p15.1-p14 KIAA1239 protein LOC389205 4 similar to LINE-1 REVERSE TRANSCRIPTASE HOMOLOG FLJ11017 4p14 hypothetical protein FLJ11017 PGM2 4p14-q12 phosphoglucomutase 2 PTTG2 4p12 pituitary tumor-transforming 2 LOC338096 4p14 proteasome activator subunit 2 pseudogene MRPS33P2 4p14 mitochondrial ribosomal protein S33 pseudogene 2 TBC1D1 4p14 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 FLJ13197 4p14 hypothetical protein FLJ13197 KLF3 4p14 Kruppel-like factor 3 (basic) TLR10 4p14 toll-like receptor 10 TLR1 4p14 toll-like receptor 1 TLR6 4p16.1 toll-like receptor 6 LOC92689 4p14 hypothetical protein BC001096 FLJ23235 4p14 hypothetical protein FLJ23235 KLHL5 4p15.1-p13 kelch-like 5 (Drosophila) PWDMP 4p14 WD repeat membrane protein PWDMP RFC1 4p14-p13 replication factor C (activator 1) 1, 145kDa LOC152831 4p14 klotho beta like RPL9 4p13 ribosomal protein L9 LIAS 4p14 lipoic acid synthetase LOC391645 4 similar to WD repeat domain 5; Bmp2-induced gene UGDH 4p15.1 UDP-glucose dehydrogenase LOC201895 4p14 hypothetical protein LOC201895 HIP2 4p14 huntingtin interacting protein 2 LOC391646 4 similar to chromosome 6 open reading frame 46; Em:AF134726.1 KIAA0648 4p15.1-p11 similar to chromosome 6 open reading frame 46; Em:AF134726.1 PABPCP1 4p14 poly(A) binding protein, cytoplasmic, pseudogene 1 LOC391647 4 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC344967 4p14 similar to cytosolic acyl coenzyme A thioester hydrolase N4BP2 4p14 Nedd4 binding protein 2 ARHH 4p13 ras homolog gene family, member H LOC339997 4p14 hypothetical LOC339997 CHRNA9 4p15.1-p14 cholinergic receptor, nicotinic, alpha polypeptide 9 FLJ20273 4p13-p12 RNA-binding protein FLJ14001 4p14 hypothetical protein FLJ14001 APBB2 4p15.1-p14 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2753 - 796 - Xu (2000)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   predominantly
     thymus    
    Reproductivefemale systemovary   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 20 tandemly repeated extracellular leucine-rich motifs(LRR)
  • a cysteine-rich region
  • a transmembrane segment
  • a cytoplasmic domain
  • the Toll homology domain common to the Toll and IL1 receptor genes (also called TIR domain)
  • HOMOLOGY
    interspecies homolog to Drosophila transmembrane receptor Toll,6
    Homologene
    FAMILY
  • Toll-like receptor family
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • transmembrane protein type I
  • TLR1, TLR2, TLR6, and TLR10 are displayed on the plasma membrane where they are best available to contact bacterial and fungal cell wall constituents
  • basic FUNCTION
  • recruited to macrophage phagosome in association to TLR2 where they recognize peptidoglycan, a Gram+ pathogen component (pathogen recognition and activation of innate immunity)
  • play a major role in initiating innate immune responses against microbes (Barreiro 2009)
  • expression of TLR6 may be a key factor in determining whether the first trimester trophoblast response to peptidoglycan would be apoptosis or inflammation (Abrahams 2008)
  • TLR1, TLR2, TLR6, and TLR10, mediates immune responses to a variety of microbial cell wall components including lipoproteins and glycolipids
  • TLR1, TLR2 and TLR6 were expressed on the surface of B cells, monocytes and dendritic cells in a manner dependent on TLR-specific chaperone CNPY3
  • lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text apoptosis of infected cells
    PATHWAY
    metabolism
    signaling signal transduction
    NF-kappa B and JNK pathways
    a component
  • heterodimerizes with TLR1 or TLR2 (Kang 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TLR2
  • activating NF-kappaBs signaling pathway
  • inducing TNF and IL6 production
  • interacting with IL10 (TLR6 is a distinct receptor driving regulatory IL10 response) (Depaolo (2008)
  • cell & other
    REGULATION
    induced by hypoxia (coordinated induction of TLR2 and TLR6 during hypoxia suggesting tissue hypoxia in transcriptional adaptation of innate immune responses during acute infection or inflammation) (Kuhlicke 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS