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Symbol TLR6 contributors: mct/npt - updated : 11-02-2013
HGNC name toll-like receptor 6
HGNC id 16711
Location 4p14      Physical location : 38.825.335 - 38.858.437
Synonym name
  • Drosophila transmembrane receptor Toll homolog 6
  • CD286 antigen
  • Synonym symbol(s) CD286
    TYPE functioning gene
    STRUCTURE 2.75 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1239 4p15.1-p14 KIAA1239 protein LOC389205 4 similar to LINE-1 REVERSE TRANSCRIPTASE HOMOLOG FLJ11017 4p14 hypothetical protein FLJ11017 PGM2 4p14-q12 phosphoglucomutase 2 PTTG2 4p12 pituitary tumor-transforming 2 LOC338096 4p14 proteasome activator subunit 2 pseudogene MRPS33P2 4p14 mitochondrial ribosomal protein S33 pseudogene 2 TBC1D1 4p14 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 FLJ13197 4p14 hypothetical protein FLJ13197 KLF3 4p14 Kruppel-like factor 3 (basic) TLR10 4p14 toll-like receptor 10 TLR1 4p14 toll-like receptor 1 TLR6 4p16.1 toll-like receptor 6 LOC92689 4p14 hypothetical protein BC001096 FLJ23235 4p14 hypothetical protein FLJ23235 KLHL5 4p15.1-p13 kelch-like 5 (Drosophila) PWDMP 4p14 WD repeat membrane protein PWDMP RFC1 4p14-p13 replication factor C (activator 1) 1, 145kDa LOC152831 4p14 klotho beta like RPL9 4p13 ribosomal protein L9 LIAS 4p14 lipoic acid synthetase LOC391645 4 similar to WD repeat domain 5; Bmp2-induced gene UGDH 4p15.1 UDP-glucose dehydrogenase LOC201895 4p14 hypothetical protein LOC201895 HIP2 4p14 huntingtin interacting protein 2 LOC391646 4 similar to chromosome 6 open reading frame 46; Em:AF134726.1 KIAA0648 4p15.1-p11 similar to chromosome 6 open reading frame 46; Em:AF134726.1 PABPCP1 4p14 poly(A) binding protein, cytoplasmic, pseudogene 1 LOC391647 4 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC344967 4p14 similar to cytosolic acyl coenzyme A thioester hydrolase N4BP2 4p14 Nedd4 binding protein 2 ARHH 4p13 ras homolog gene family, member H LOC339997 4p14 hypothetical LOC339997 CHRNA9 4p15.1-p14 cholinergic receptor, nicotinic, alpha polypeptide 9 FLJ20273 4p13-p12 RNA-binding protein FLJ14001 4p14 hypothetical protein FLJ14001 APBB2 4p15.1-p14 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2753 - 796 - Xu (2000)
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   predominantly
    Reproductivefemale systemovary   
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
  • 20 tandemly repeated extracellular leucine-rich motifs(LRR)
  • a cysteine-rich region
  • a transmembrane segment
  • a cytoplasmic domain
  • the Toll homology domain common to the Toll and IL1 receptor genes (also called TIR domain)
    interspecies homolog to Drosophila transmembrane receptor Toll,6
  • Toll-like receptor family
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
  • transmembrane protein type I
  • TLR1, TLR2, TLR6, and TLR10 are displayed on the plasma membrane where they are best available to contact bacterial and fungal cell wall constituents
  • basic FUNCTION
  • recruited to macrophage phagosome in association to TLR2 where they recognize peptidoglycan, a Gram+ pathogen component (pathogen recognition and activation of innate immunity)
  • play a major role in initiating innate immune responses against microbes (Barreiro 2009)
  • expression of TLR6 may be a key factor in determining whether the first trimester trophoblast response to peptidoglycan would be apoptosis or inflammation (Abrahams 2008)
  • TLR1, TLR2, TLR6, and TLR10, mediates immune responses to a variety of microbial cell wall components including lipoproteins and glycolipids
  • TLR1, TLR2 and TLR6 were expressed on the surface of B cells, monocytes and dendritic cells in a manner dependent on TLR-specific chaperone CNPY3
  • lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text apoptosis of infected cells
    signaling signal transduction
    NF-kappa B and JNK pathways
    a component
  • heterodimerizes with TLR1 or TLR2 (Kang 2009)
    small molecule
  • TLR2
  • activating NF-kappaBs signaling pathway
  • inducing TNF and IL6 production
  • interacting with IL10 (TLR6 is a distinct receptor driving regulatory IL10 response) (Depaolo (2008)
  • cell & other
    induced by hypoxia (coordinated induction of TLR2 and TLR6 during hypoxia suggesting tissue hypoxia in transcriptional adaptation of innate immune responses during acute infection or inflammation) (Kuhlicke 2007)