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FLASH GENE
Symbol TLR10 contributors: mct/npt - updated : 17-02-2010
HGNC name toll-like receptor 10
HGNC id 15634
Location 4p14      Physical location : 38.773.859 - 38.784.611
Synonym name
  • Drosophila transmembrane receptor Toll homolog 10
  • CD290 antigen
  • Synonym symbol(s) CD290, MGC104967, MGC126398, MGC126399
    DNA
    TYPE functioning gene
    STRUCTURE 10.36 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC42157 4p15.1 hypothetical protein MGC42157 KIAA1239 4p15.1-p14 KIAA1239 protein LOC389205 4 similar to LINE-1 REVERSE TRANSCRIPTASE HOMOLOG FLJ11017 4p14 hypothetical protein FLJ11017 PGM2 4p14-q12 phosphoglucomutase 2 PTTG2 4p12 pituitary tumor-transforming 2 LOC338096 4p14 proteasome activator subunit 2 pseudogene MRPS33P2 4p14 mitochondrial ribosomal protein S33 pseudogene 2 TBC1D1 4p14 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 FLJ13197 4p14 hypothetical protein FLJ13197 KLF3 4p14 Kruppel-like factor 3 (basic) TLR10 4p14 toll-like receptor 10 TLR1 4p14 toll-like receptor 1 TLR6 4p16.1 toll-like receptor 6 LOC92689 4p14 hypothetical protein BC001096 FLJ23235 4p14 hypothetical protein FLJ23235 KLHL5 4p15.1-p13 kelch-like 5 (Drosophila) PWDMP 4p14 WD repeat membrane protein PWDMP RFC1 4p14-p13 replication factor C (activator 1) 1, 145kDa LOC152831 4p14 klotho beta like RPL9 4p13 ribosomal protein L9 LIAS 4p14 lipoic acid synthetase LOC391645 4 similar to WD repeat domain 5; Bmp2-induced gene UGDH 4p15.1 UDP-glucose dehydrogenase LOC201895 4p14 hypothetical protein LOC201895 HIP2 4p14 huntingtin interacting protein 2 LOC391646 4 similar to chromosome 6 open reading frame 46; Em:AF134726.1 KIAA0648 4p15.1-p11 similar to chromosome 6 open reading frame 46; Em:AF134726.1 PABPCP1 4p14 poly(A) binding protein, cytoplasmic, pseudogene 1 LOC391647 4 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC344967 4p14 similar to cytosolic acyl coenzyme A thioester hydrolase N4BP2 4p14 Nedd4 binding protein 2 ARHH 4p13 ras homolog gene family, member H LOC339997 4p14 hypothetical LOC339997 CHRNA9 4p15.1-p14 cholinergic receptor, nicotinic, alpha polypeptide 9 FLJ20273 4p13-p12 RNA-binding protein FLJ14001 4p14 hypothetical protein FLJ14001 APBB2 4p15.1-p14 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3088 - 811 - Chuang (2001)
    4 - 3594 - 811 - Chuang (2001)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Lymphoid/Immunelymph node    
    Reproductivefemale systemoviduct   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunelymphocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tandemly repeated extracellular leucine-rich motifs(LRR)
  • a cysteine-rich region
  • a transmembrane segment and a cytoplasmic domain
  • the toll homology domain common to the Toll and IL1 receptor genes (also called TIR domain), highly conserved signaling domain found in the intracellular regions, mediating receptor signal transduction through recruitment of adaptor proteins and playing critical roles in the innate immune response and inflammation (Nyman 2008)
  • HOMOLOGY
    interspecies homolog to Drosophila transmembrane receptor Toll
    intraspecies homolog to TOLL1,TOLL6
    Homologene
    FAMILY
  • toll-like receptor family
  • CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • transmembrane protein type I
  • TLR1, TLR2, TLR6, and TLR10 are displayed on the plasma membrane where they are best available to contact bacterial and fungal cell wall constituents
  • basic FUNCTION
  • pathogen component (pathogen recognition and activation of innate immunity), mediating the production of cytokines
  • play a major role in initiating innate immune responses against microbes (Barreiro 2009)
  • recognize specific pathogen-associated molecular patterns and to alarm immunocompetent cells to trigger an immune response (Muzio 2009)
  • playing a potential role in modulating Chronic Lymphocytic Leukaemia cell response in the context of specific antigen recognition (Muzio 2009)
  • TLR1, TLR2, TLR6, and TLR10, mediates immune responses to a variety of microbial cell wall components including lipoproteins and glycolipids
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text immune response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating NF-kappaBs signaling pathway
  • cell & other
    REGULATION
    induced by in primary T regulatory (Treg) cells in a calcium-dependent fashion through TCR activation (Bell 2007)
    Other regulated by FOXP3 (regulates TLR10 expression in human T regulatory cells) (Bell 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS