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FLASH GENE
Symbol TLNRD1 contributors: mct - updated : 14-11-2019
HGNC name talin rod domain containing 1
HGNC id 13519
Location 15q25.1      Physical location : -
Synonym name
  • mesoderm development candidate 1
  • Synonym symbol(s) MGC99595, MESDC1
    DNA
    TYPE functioning gene
    STRUCTURE 4.87 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4866 37.6 362 - 2010 20610383
    EXPRESSION
    Rna function mRNA is widely expressed
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveliver    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region (residues 1–43) has no homologues
  • homology with TLN1 is restricted to 301 AAs at the C terminus
  • secondary structure
  • secondary structure predictions suggest that the N-ter region forms a 24-AAs-long helix
  • secondary structure prediction clearly indicates that AAs 44–352 have a similar secondary structure to TLN1 AAs 1359–1659
  • HOMOLOGY
    interspecies homolog to murine Mesdc1
    intraspecies homolog to talin AAs 1359–1659 in the central rod
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • actin-binding protein
  • predicted to be a novel actin-binding protein
  • having a potential oncogenic function in bladder cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS