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FLASH GENE
Symbol TLL2 contributors: npt/ - updated : 16-02-2005
HGNC name tolloid-like 2
HGNC id 11844
Location 10q23-q24      Physical location : 98.124.362 - 98.273.683
Synonym name related to procollagen C proteinase
Synonym symbol(s) KIAA0932, MGC133312, MGC133313
EC.number 3.4.24.-
DNA
TYPE functioning gene
STRUCTURE 149.30 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CYP2C8 10q23.33 cytochrome P450, family 2, subfamily C, polypeptide 8 LOC387705 10 LOC387705 LOC142827 10q24.1 similar to Hypothetical protein MGC56918 PDLIM1 10q22-q26.3 PDZ and LIM domain 1 (elfin) SORBS1 10q23.3-q24.1 sorbin and SH3 domain containing 1 LOC389999 10 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 PYCS 10q24.3 pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase) DKFZP564D116 10q24.1 DKFZP564D116 protein ENTPD1 10q24 ectonucleoside triphosphate diphosphohydrolase 1 LOC387706 10 LOC387706 LOC387707 10 similar to RIKEN cDNA 5730509K17 gene FLJ10895 10pter-q26.12 hypothetical protein FLJ10895 KIAA0335 10cen-q26.11 hypothetical protein FLJ10895 LOC387708 10 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 BLNK 10q23.2 B-cell linker DNTT 10q24 deoxynucleotidyltransferase, terminal TMEM10 10q23-q24 transmembrane protein 10 TLL2 10q23-q24 tolloid-like 2 SMBP 10q24.2 SM-11044 binding protein PIK3AP1 10q24.2 phosphoinositide-3-kinase adaptor protein 1 LOC283340 10q24.2 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC387709 10 LOC387709 C10orf12 10q24.2 chromosome 10 open reading frame 12 SLIT1 10q23.3-q24 slit homolog 1 (Drosophila) ARHGAP19 10q24.2 Rho GTPase activating protein 19 FRAT1 10q24.1 frequently rearranged in advanced T-cell lymphomas FRAT2 10q23-q24.1 frequently rearranged in advanced T-cell lymphomas 2 KIAA0690 10q23.33 frequently rearranged in advanced T-cell lymphomas 2 PGAM1 10q25.3 phosphoglycerate mutase 1 (brain) CSL4 10q24 exosomal core protein CSL4 ZDHHC16 10q24.1 zinc finger, DHHC domain containing 16 MMS19L 10q24-q25 MMS19-like (MET18 homolog, S. cerevisiae) FLJ11807 10q24.2 hypothetical protein FLJ11807 ANKRD2 10q23.31-q23.32 ankyrin repeat domain 2 (stretch responsive muscle)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 6753 113.4 1015 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a proregion the protease domain
  • five CUB domain
  • an EGF domain
  • conjugated GlycoP
    HOMOLOGY
    intraspecies paralog to TLL1
    homolog to procollagen C proteinase
    paralog to TLL1
    Homologene
    FAMILY
  • astacin family of metalloproteinases
  • peptidase M12A family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • metallopeptidase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS