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FLASH GENE
Symbol TLE4 contributors: mct - updated : 24-05-2014
HGNC name transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
HGNC id 11840
Location 9q21.31      Physical location : 82.186.877 - 82.341.657
Synonym name
  • transducin-like enhancer of split 4, homolog of Drosophila E(sp1)
  • enhancer of split groucho 4
  • protein BCE-1
  • B lymphocyte gene 1
  • Synonym symbol(s) ESG, ESG4, KIAA1261, BCE-1, BCE1, E(spI), GRG4
    DNA
    TYPE functioning gene
    STRUCTURE 155.11 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text a major 5.1- and a minor 2.8-kb transcript (Stifani 1992)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1177 - 94 B cells Milili (2002)
  • also called QD
  • contains the first four TLE4 exons and an intronic sequence 3' of exon 4
  • act as a negative regulator of TLE4 function, in early B-cell differentiation
  • 20 - 4749 - 773 - Milili (2002)
    21 - 5173 - 652 - -
    21 - 5174 - 805 - -
    18 - 4871 - 704 - -
    19 - 5003 - 748 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainbasal nucleicaudate nucleus highly Homo sapiensFetal
    Urinarykidney     Homo sapiensFetal
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  highly Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • casein kinase II site/nuclear localization sequence motif with a pleckstrin homology (PH) domain
  • seven WD repeats (Trp-Asp domains)
  • conjugated PhosphoP
    mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies homolog to murine Tle4 (99.6pc)
    homolog to Drosophila spl
    homolog to rattus Tle4 (95.4pc)
    Homologene
    FAMILY
  • WD repeat Groucho/TLE family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • enhancer of split groucho 4
  • required for cell fate decisions
  • transcriptional corepressor that binds to a number of transcription factors
  • inhibits the transcriptional activation mediated by PAX5 and by CTNNB1 and TCF family members of Wnt signaling
  • can regulate diverse signaling pathways, such as Wnt, Notch and EGF signaling
  • TLE4 dependent activation of the BMP pathway is most likely mediated by a reduction of inhibitory Smads
  • can play an important role in regulating BMP7 mediated activation of reporter and endogenous genes
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with QD and inhibiting TLE4-PAX5 interactions (Milili 2002)
  • interacting with MEIS2 (competes with the Groucho co-repressor TLE4 for binding to OTX2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer) (Agoston 2009)
  • TLE4 recruitment by the PAX2 DNA binding protein inhibits gene expression by displacing the co-activator PTIP and subsequently recruiting the Polycomb repressor 2 complexes (PRC2)
  • interaction between OTX2 and TLE4 co-repressors regulates GNRH1 gene expression in hypothalamic neurons (Larder 2009)
  • PRMT5 is essential for recruiting Polycomb proteins, in a PAX2/TLE4 dependent manner, which results in H3K27 methylation
  • binding PAX5, LEF1, TCF7, TCF7L1, TCF7L2
  • interaction between TLE4 and BMP signaling
  • PRDM1-dependent recruitment of TLE4 to the IFNG locus causes epigenetic silencing of the expression of the IFNG gene in anergic TH1 cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS