protein
| interacting with QD and inhibiting TLE4-PAX5 interactions (Milili 2002) |
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interacting with MEIS2 (competes with the Groucho co-repressor TLE4 for binding to OTX2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer) (Agoston 2009) |
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TLE4 recruitment by the PAX2 DNA binding protein inhibits gene expression by displacing the co-activator PTIP and subsequently recruiting the Polycomb repressor 2 complexes (PRC2) |
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interaction between OTX2 and TLE4 co-repressors regulates GNRH1 gene expression in hypothalamic neurons (Larder 2009) |
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PRMT5 is essential for recruiting Polycomb proteins, in a PAX2/TLE4 dependent manner, which results in H3K27 methylation |
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binding PAX5, LEF1, TCF7, TCF7L1, TCF7L2 |
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interaction between TLE4 and BMP signaling |
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PRDM1-dependent recruitment of TLE4 to the IFNG locus causes epigenetic silencing of the expression of the IFNG gene in anergic TH1 cells |