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FLASH GENE
Symbol TKFC contributors: mct - updated : 05-03-2020
HGNC name triokinase and FMN cyclase
HGNC id 24552
Corresponding disease
TKFCD TKFC deficiency
Location 11q12.2      Physical location : -
Synonym name
  • dihydroxyacetone kinase 2 homolog (yeast)"
  • glycerone kinase
  • DHA kinase
  • dihydroxyacetone kinase 2 homolog (S. cerevisiae)
  • FAD-AMP lyase cyclic FMN forming
  • FAD-AMP lyase cyclizing
  • testis tissue sperm-binding protein Li 84P
  • Synonym symbol(s) MGC5621, NET45, DAK, MGC5621, DKFZp586B1621
    EC.number 2.7.1.29/ 4.6.1.15/ 2.7.1.29
    DNA
    TYPE functioning gene
    STRUCTURE 20.24 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2252 - 598 - 2014 24569995
    18 - 2399 - 568 - 2014 24569995
    19 - 4780 - 575 - 2014 24569995
    19 - 4349 - 464 - 2014 24569995
    18 - 4251 - 534 - 2014 24569995
    18 - 4678 - 575 - 2014 24569995
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  predominantly Homo sapiens
     liver   predominantly Homo sapiens
    Reproductivemale systemprostate  highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DAK1 (dihydroxyacetone kinase subunit 1) domain
  • a DAK2 (dihydroxyacetone kinase subunit 2) domain
  • an FMN lyase domain
  • HOMOLOGY
    Homologene
    FAMILY dihydroxyacetone kinase (DAK) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the phosphorylation of dihydroxyacetone
  • physiological suppressor of IFIH1 and specifically inhibits IFIH1- but not DDX58-mediated innate antiviral signaling
  • phosphorylates exogenous dihydroxyacetone and fructose-derived glyceraldehyde, is neither molecularly identified nor firmly associated to an encoding gene
  • catalyzes the adenosine triphosphate (ATP)-dependent phosphorylation of D-glyceraldehyde and dihydroxyacetone (DHA), and the cyclizing splitting of flavin adenine dinucleotide (FAD)
  • bifunctional enzyme involved in fructose metabolism through its glyceraldehyde kinase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein specific IFIH1-interacting protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TKFCD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS