Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TJP3 contributors: mct - updated : 04-02-2012
HGNC name tight junction protein 3 (zona occludens 3)
HGNC id 11829
Location 19p13.3      Physical location : 3.728.373 - 3.750.681
Synonym symbol(s) ZO-3, MGC119546
DNA
TYPE functioning gene
STRUCTURE 22.31 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390876 19 similar to ribosomal protein L35 GNA15 19p13.3 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) LOC388491 19 similar to KIAA1683 protein EDG6 19p13.3 endothelial differentiation, G-protein-coupled receptor 6 LOC56926 19p13.3 hypothetical protein from EUROIMAGE 2021883 BRUNOL5 19p13 bruno-like 5, RNA binding protein (Drosophila) NFIC 19p13.3 nuclear factor I/C (CCAAT-binding transcription factor) LOC284422 19p13.3 similar to HSPC323 MGC4293 19p13.3 hypothetical protein MGC4293 FZR1 19p13.3 hypothetical protein MGC4293 LOC388492 19 LOC388492 MGC20700 19p13.3 hypothetical protein MGC20700 HMG20B 19p13.3 high-mobility group 20B GIPC3 19p13.3 PDZ domain protein GIPC3 LOC388493 19 similar to putative protein (5J182) TBXA2R 19p13.3 thromboxane A2 receptor PIP5K1C 19p13.3 phosphatidylinositol-4-phosphate 5-kinase, type I, gamma TJP3 19p13.3 tight junction protein 3 (zona occludens 3) APBA3 19p13.3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2) MRPL54 19p13.3 mitochondrial ribosomal protein L54 MGC15631 19p13.3 hypothetical protein MGC15631 MATK 19p13.3 megakaryocyte-associated tyrosine kinase KIAA1086 19p13.3 megakaryocyte-associated tyrosine kinase LOC388494 19 hypothetical gene supported by AL365406; BC034005 ATCAY 19p13.3 ataxia, cerebellar, Cayman type (caytaxin) ITGB1BP3 19p13.3 integrin beta 1 binding protein 3 DAPK3 19p13.3 death-associated protein kinase 3 EEF2 19p13.3 eukaryotic translation elongation factor 2 PIASY 19p13.3 protein inhibitor of activated STAT protein PIASy LOC387622 19 hypothetical gene supported by NM_020224 FBI1 MAP2K2 7q32 mitogen-activated protein kinase kinase 2 CREB3L3 19p13.3 cAMP responsive element binding protein 3-like 3 SIRT6 19p13.3 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) KIAA1981
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 2859 - 952 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrinepancreas    
Nervousbrain    
Reproductivefemale systemovary  highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal (MAGUK-like)
  • three Dlg (DHR/GLGZ/PDZ) motifs with a proline-rich region between PDZ2 and PDZ3
  • a SH3 domain
  • a C terminal acidic domain
  • HOMOLOGY
    interspecies homolog to yeast guanylate kinase
    homolog to Drosophila lethal dics large tumor suppressor protein Dlg
    homolog to murine Tjp3
    Homologene
    FAMILY MAGUK (membrane-associated guanylate kinase homolog) superfamily of cell junction proteins
    CATEGORY adhesion , chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • tight junction and zona occludens
  • shows an epithelial-specific Tight junction localization in a TJP1/TJP2-dependent fashion
  • basic FUNCTION
  • F actin filament binding scaffold protein, mediating interactions with claudins in tight junction plaques
  • important role in regulating epithelial cell proliferation through stabilization of cyclin D1 during mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component structural component of tight junction and adherens junction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly to the C terminus of claudins, occludin and ZO-1
  • can associate with INADL (INADL/TJP3 interaction is likely important for recruiting INADL and its associated proteins to tight junctions)
  • bind to the C-terminus of OCLN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS