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Symbol TIPRL contributors: mct/npt - updated : 25-11-2009
HGNC name TIP41 TOR signaling pathway regulator-like (S. cerevisiae)
HGNC id 30231
Location 1q24.2      Physical location : 168.148.170 - 168.171.349
Synonym name
  • type 2A-interacting protein
  • target of rapamycin signaling pathway regulator-like
  • putative MAPK-activating protein PM10
  • yeast YPR037W and worm C02C2.6 predicted proteins-like
  • Synonym symbol(s) TIP, TIP41, MGC3794, dJ69E11.3, RP1-69E11.1, CG9578-like
    DNA
    TYPE functioning gene
    STRUCTURE 23.18 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3032 - 272 - -
    5 - 854 - 178 - McConnell (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • TIP41 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • inhibitory regulator of PP2A and implicate a role for TIP/PP2A complexes within the ATM/ATR signaling pathway controlling DNA replication and repair (McConnell 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulatory protein of PPP2R4 and the PP2A-like enzymes PPP4C and TMEM115 (interacts with the C-terminal region of the catalytic subunits of PPP2R4, PPP4C and TMEM115)(McConnell 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS