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FLASH GENE
Symbol TIPIN contributors: mct - updated : 17-06-2014
HGNC name timeless-interacting protein
HGNC id 30750
Location 15q22.31      Physical location : 66.629.007 - 66.649.054
Synonym symbol(s) FLJ20516
DNA
TYPE functioning gene
STRUCTURE 20.05 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1295 34.4 301 - 2007 1710213
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
Lymphoid/Immunespleen    
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila circadian
Homologene
FAMILY
  • CSM3 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in biochemical pathways controlling vital cellular functions
  • functional complex with TIMELESS
  • TIMELESS-TIPIN complex stabilizes replication forks both by preventing the accumulation of ssDNA upstream of ATR-CHEK1 function and by facilitating phosphorylation of CHEK1 by ATR
  • ARHGEF5/TIPIN complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins
  • ARHGEF5-TIPIN complex plays important roles in S phase progression, stabilization of stalled replication forks, and checkpoint activation
  • functions in the protection against topoisomerase I inhibitor
  • MTA2 and TIPIN cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TIMELESS-TIPIN complex, a component of the replication fork machinery, plays a role in replication checkpoint activation and stabilization of the replication fork
  • WDHD1-CLSPN-TIPIN-TIMELESS complex, which coordinate DNA unwinding with polymerase alpha-, delta-, and epsilon- dependent DNA polymerization are constituents of the Replisome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 (Numata 2010)
  • RPA1-covered ssDNA not only supports recruitment and activation of ATR but also, through TIPIN and CLSPN, it plays an important role in the action of ATR on its critical downstream target CHEK1
  • RPA2 also interacts with TIPIN during the intra-S checkpoint
  • TIMELESS protein associates with S phase replication checkpoint proteins CLSPN and TIPIN , and plays an important role in maintaining replication fork stability at physical barriers, like centromeres, telomeres and ribosomal DNA repeats, as well as at termination sites
  • ARHGEF5-TIPIN complex might couple DNA unwinding and DNA synthesis by affecting the biochemical properties of these replisome proteins
  • ARHGEF5 is responsible for the interaction between the ARHGEF5-TIPIN and Mcm complexes
  • MTA2, a subunit of the NuRD chromatin remodeler complex, is a novel TIPIN binding partner and mediator of its function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS