Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TIPARP contributors: mct - updated : 23-03-2011
HGNC name TCDD-inducible poly(ADP-ribose) polymerase
HGNC id 23696
Location 3q25.31      Physical location : 156.392.204 - 156.424.555
Synonym symbol(s) DDF1, PARP7, PARP-1, PARP-7, DKFZp434J214, DKFZp686N0351, DKFZp686P1838, FLJ40466, ARTD14
DNA
TYPE functioning gene
STRUCTURE 32.35 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4047 - 657 - 2003 12851707
6 - 4132 - 657 - 2003 12851707
6 - 3697 - 657 - 2003 12851707
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a TPH domain
  • a WWE domain
  • a PARP-like domain
  • CCCH-type zinc finger within the N-terminal part of the TPH domain
  • HOMOLOGY
    interspecies ortholog to murine Tiparp
    Homologene
    FAMILY TIPARP family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • can mediate a toxin TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin, dioxin) effect
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ovarian cancer
    Variant & Polymorphism SNP rs2665390 significantly associated to ovarian cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS