basic FUNCTION
| negative regulator of telomerase length, stabilising TTAGGG repeats |
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ADPRT modulator in the TERF1 complex and contributing to the regulation of the telomere length |
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crucial for anchoring the TPP1-POT1-telomerase complex to the telomeres |
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plays a central role in the assembly and function of the six-protein complex, connecting the double-stranded DNA-binding proteins TERF1 (telomere repeat binding factor) and TERF2 to the single-stranded DNA-binding unit TPP1/POT1 |
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dual role for TINF2 in mediating the function of the shelterin complex and tethering telomeres to the nuclear matrix |
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TINF2-anchored ACD plays a major role in the recruitment of telomerase to telomeres in cells |
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participate in the TPP1-dependent recruitment of telomerase activity |
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recruits the telomerase in a TPP1-dependent manner |
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may specifically regulate the telomerase that has been recruited to the telomeres rather than total telomerase activity |
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essential for early embryonic development and for development of a variety of malignancies |
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preferential recruitment of shelterin complex to areas of the telomere where ss- and ds-DNA are in close proximity, such as the 3prime-telomeric overhang, telomeric DNA bubbles and the D-loop at the base of T-loops |
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SIAH2-mediated removal of TINF2 may allow dynamic remodeling of the shelterin complex and its associated factors during the cell cycle |
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also affected the TERF2-dependent repression of ATM kinase signaling but not to TERF2-mediated inhibition of telomere fusions |
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likely a direct role for TINF2 in mediating telomere length through telomerase, separable from its role in telomere protection |