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FLASH GENE
Symbol TINCR contributors: mct - updated : 28-05-2015
HGNC name tissue differentiation-inducing non-protein coding RNA
HGNC id 14607
Location 19p13.3      Physical location : -
Synonym symbol(s) NCRNA00036, PLAC2
DNA
TYPE small rna
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type untranslated
EXPRESSION
Rna function
  • strongly upregulated in gastric carcinoma (GC), where it was found to contribute to oncogenesis and cancer progression, contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease
  • role for TINCR as an epithelial-specific guide for targeting the STAU1 protein to specific mRNAs, reflecting the increasing complexity of gene regulatory processes in mammalian cells and tissue
  • key lncRNA required for somatic tissue differentiation, which occurs through lncRNA binding to differentiation mRNAs to ensure their expression
  • regulates epidermal differentiation genes involved in barrier formation
  • TINCR could bind to STAU1 (staufen1) protein, and influence CDKN2B mRNA stability and expression, thereby affecting the proliferation of gastric cancer (GC)cells
  • Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS