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FLASH GENE
Symbol TIMP4 contributors: - updated : 05-05-2004
HGNC name tissue inhibitor of metalloproteinase 4
HGNC id 11823
Location 3p25      Physical location : 12.194.572 - 12.200.647
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene
text maybe embedded in intron V of SYN2
STRUCTURE 5.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC389095 3 LOC389095 SLC6A11 3p25.2 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 SLC6A1 3p25-p24 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 LOC391509 3 similar to Drosophila melanogaster CG8797 gene product-related LOC391510 3 similar to FLJ31709 protein HRH1 3p25 histamine receptor H1 APG7L 3p25.3-3p24.1 APG7 autophagy 7-like (S. cerevisiae) KIAA0121 3p25.2 KIAA0121 gene product LOC132001 3p25.2 hypothetical protein BC015088 DKFZp434E0519 3p25.2 hypothetical protein DKFZp434E0519 HCP12 3p25.2 cytochrome c, somatic pseudogene SYN2 3p25 synapsin II TIMP4 3p25 tissue inhibitor of metalloproteinase 4 LOC391511 3 similar to Glutathione S-transferase Mu 1 (GSTM1-1) (HB subunit 4) (GTH4) (GSTM1a-1a) (GSTM1b-1b) (GST class-mu 1) PPARG 3p25 peroxisome proliferative activated receptor, gamma MGC2776 3p25.2 hypothetical protein MGC2776 MKRN2 3p25 makorin, ring finger protein, 2 RAF1 3p25 v-raf-1 murine leukemia viral oncogene homolog 1 FLJ11036 3p25.2 hypothetical protein FLJ11036 LOC344866 3p25.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) TIP120B 3p25.2-p24.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) RPL32 3p25-p24 ribosomal protein L32 LOC391512 3 similar to WD repeat domain 10 isoform 3 LOC391513 3 similar to ENSANGP00000014786 LOC391514 3 similar to MAP/microtubule affinity-regulating kinase 1 LOC389096 3 similar to nucleoporin 210; nuclear pore membrane glycoprotein 210; gp210 KIAA0763 3p25.1 similar to nucleoporin 210; nuclear pore membrane glycoprotein 210; gp210 NUP210 3p25.2-p25.1 nucleoporin 210 HDAC11 3p25.1 histone deacetylase 11 FBLN2 3p25-p24 fibulin 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
12 cysteine residues that form six disulfide bridges
conjugated MetalloP
HOMOLOGY
Homologene
FAMILY TIMP family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • matrix metalloproteinase, tissue inhibitor 4
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding MMPs in a 1:1 stoechiometry
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS