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FLASH GENE
Symbol TIMP2 contributors: mct - updated : 28-11-2009
HGNC name TIMP metallopeptidase inhibitor 2
HGNC id 11821
Location 17q25.3      Physical location : 76.849.062 - 76.921.472
Synonym name tissue inhibitor of metalloproteinase 2
Synonym symbol(s) CSC-21K, TIMP-2
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene, antisens
text may be embedded in one intron of SYN4, as other TIMPs are in other SYNs
STRUCTURE 72.41 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure five Sbeta1, two AP-2, one AP-1, three PEA-3
MAPPING cloned Y linked N status confirmed
Physical map
EVER1 17q25.3 epidermodysplasia verruciformis 1 EVER2 17q25.3 epidermodysplasia verruciformis 2 EIF5AP2 17q25 eukaryotic translation initiation factor 5A pseudogene 2 SYNGR2 17q25.3 synaptogyrin 2 TK1 17q25.1 thymidine kinase 1, soluble LOC125061 BIRC5 17q25 baculoviral IAP repeat-containing 5 (survivin) LOC283999 17q25.3 hypothetical protein LOC283999 LOC390816 17 similar to RIKEN cDNA 1300017K07 SOCS3 17q25.3 suppressor of cytokine signaling 3 LOC388421 17 LOC388421 PGS1 17q25.3 phosphatidylglycerophosphate synthase FLJ40457 17q25.3 hypothetical protein FLJ40457 LOC284120 17q25.3 hypothetical LOC284120 PSCD1 17q25-qter pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) USP36 17q25.3 ubiquitin specific protease 36 TIMP2 17q25..3 tissue inhibitor of metalloproteinase 2 LGALS3BP 17q25.2-q25.3 lectin, galactoside-binding, soluble, 3 binding protein SHAPY 17q25.3 Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase C1QTNF1 17q25.2 C1q and tumor necrosis factor related protein 1 LOC388422 17 LOC388422 FLJ21865 17q25.3 endo-beta-N-acetylglucosaminidase LOC339162 17q25.3 similar to ataxin 2-binding protein 1 isoform 2; hexaribonucleotide binding protein 1 LOC388423 17 LOC388423
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 polyA site 3670 21.75 220 - 1992 1427908
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Rattus norvegicusFetal
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Rattus norvegicusFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 cysteine residues that form six disulfide bridges
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • protease inhibitor I35 (TIMP) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inhibits all MMPs
  • erythroid potentiating and cell growth-promoting activities
  • inhibits endothelial cell growth
  • reduces tumor growth when it's overexpressed
  • participates in metanephric mesenchymal growth and in morphogenesis of the ureteric bud
  • antiapoptotic activity
  • with MMP14, control cell proliferation and migration through a non-proteolytic mechanism
  • role for MMP14/TIMP-2 interaction, in controling cell functions by a mechanism independent of extracellular matrix degradation
  • inhibiting ADAM12 and ADAM17
  • TIMP2 and TIMP3 play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may be associated with SYN4
  • positive regulator of MMP14 by promoting the availability of MMP14 at the all surface and supporting pericellular proteolysis (complex trimolecular MMP-14, TIMP2, proMMP2)
  • binding MMPs in a 1:1 stoechiometry
  • binding to MMP14 induces activation of ERK1/2 by a mechanism that does not require the proteolytic activity and is mediated by the cytoplasmic tail of MMP14
  • MMP10 interacting with tissue inhibitors of metalloproteinases TIMP1 and TIMP2
  • MIR17 targets TIMP1 and TIMP2 to modulate cardiac matrix remodeling
  • cell & other
    REGULATION
    Other activation of proMMP2 (for normal development)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in thymoma with poor prognosis
    tumoral     --low  
    by aberrant hypermethylation in cervical carcinoma
    tumoral     --over  
    in esophageal squamous cell carcinoma
    tumoral       loss of function
    in Hodgkin and Reed-Sternberg cells
    constitutional     --over  
    in the synovium and cartilage of osteoarthritis
    tumoral     --over  
    is associated with accumulation of the pleural effusion in malignancy
    Susceptibility
    Variant & Polymorphism
    Candidate gene determination of TIMP2 in pleural fluid may contribute to differentiate tuberculous pleurisy (TP) from malignat pleurisy (MP)
    Marker
    Therapy target
    ANIMAL & CELL MODELS