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FLASH GENE
Symbol TIMM9 contributors: npt/mct - updated : 25-08-2010
HGNC name translocase of inner mitochondrial membrane 9 homolog (yeast)
HGNC id 11819
Location 14q23.1      Physical location : 58.875.370 - 58.894.232
Synonym name
  • translocase of inner mitochondrial membrane 9 homolog
  • mitochondrial import inner membrane translocase subunit Tim9
  • Synonym symbol(s) TIM9A, TIM9
    DNA
    TYPE functioning gene
    STRUCTURE 18.86 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D14S274 - TIMM9 - D14S1038 - qter
    Authors Jin (99)
    Physical map
    C14orf108 14q22.2 chromosome 14 open reading frame 108 C14orf35 14q22.2 chromosome 14 open reading frame 35 C14orf105 14q22.2 chromosome 14 open reading frame 105 LOC341880 LOC256755 14q22.3 similar to TLS-associated protein TASR-2 LOC390481 14 LOC390481 UBA52P3 14 ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 3 ACTR10 14q22.2 actin-related protein 10 homolog (S. cerevisiae) PSMA3 14q23 proteasome (prosome, macropain) subunit, alpha type, 3 HMGB1P 14 high-mobility group box 1 pseudogene RBBP1 14q22.3 retinoblastoma binding protein 1 LOC387990 14 similar to TIMM9 TIMM9 14q22.3-q24 translocase of inner mitochondrial membrane 9 homolog (yeast) KIAA0586 14q23.1 KIAA0586 HSBP1P1 14 heat shock factor binding protein 1 pseudogene 1 HNRPCP 14 heterogeneous nuclear ribonucleoprotein C pseudogene DACT1 14q22.3 dapper homolog 1, antagonist of beta-catenin (xenopus) LOC387991 14 similar to ribosomal protein L31 LOC390482 14 similar to Aldo-keto reductase family 1, member B1 PPIAP5 14 peptidylprolyl isomerase A (cyclophilin A) pseudogene 5 DAAM1 14q22.3 dishevelled associated activator of morphogenesis 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1108 10.25 89 - Webb (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a largely alpha-helical structure, one on the N terminal region
  • two cysteine residues
  • a central loop flanked by disulfide bonds that separate two extended N- and C-terminal tentacle-like helices (Baker 2009)
  • a third one and separated from each other by random coil and suggesting a hairpin of helices held together by the cysteine coodination of the Zn2 + ion
  • a region of nine AAs, functioning as a signal for the engagement of substrate proteins, and facilitating the transfer of proteins across the outer membrane to the intermembrane space (Milenkovic 2009)
  • HOMOLOGY
    interspecies homolog to yeast translocase of inner mitochondrial membrane 9
    ortholog to yeast S.cerevisiae Tim9p
    Homologene
    FAMILY
  • small Tim family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,interspace
    text mitochondrial TIMM9-TIMM10 translocase complex, located in the mitochondrial intermembrane space (Ivanova 2008)
    basic FUNCTION
  • involved in the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane
  • with TIMM10, plays an essential chaperone-like role during the import of mitochondrial membrane proteins (Ivanova 2008)
  • TIMM9-TIMM10 complex plays an essential role in mitochondrial protein import by chaperoning select hydrophobic precursor proteins across the intermembrane space (Baker 2009)
  • plays an important functional role that includes facilitating the initial steps in translocating precursor substrates into the intermembrane space (Baker 2010)
  • role for the TIMM9-TIMM10 complex in the import of Tafazzin (TAZ) and TIMM22, but not TIMM23 (Hasson 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
  • complexing with Tim10p and essential for escorting a class of multimembrane-spanning proteins
  • TIM22 protein import pathway consists of two intermembrane space chaperone complexes, the TIMM9-TIMM10 and TIMM8A-TIMM13 complexes (Hasson 2010)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS